Transcription Factor Substitution during the Evolution of Fungal Ribosome Regulation

@article{citeulike:2566542, abstract = {Summary Coordinated ribosomal protein (RP) gene expression is crucial for cellular viability, but the transcriptional network controlling this regulon has only been well characterized in the yeast Saccharomyces cerevisiae. We have used whole-genome transcriptional and location profiling to establish that, in Candida albicans, the RP regulon is controlled by the Myb domain protein Tbf1 working in conjunction with Cbf1. These two factors bind both the promoters of RP genes and the rDNA locus; Tbf1 activates transcription at these loci and is essential. Orthologs of Tbf1 bind TTAGGG telomeric repeats in most eukaryotes, and TTAGGG cis-elements are present upstream of RP genes in plants and fungi, suggesting that Tbf1 was involved in both functions in ancestral eukaryotes. In all Hemiascomycetes, Rap1 substituted Tbf1 at telomeres and, in the S. cerevisiae lineage, this substitution also occurred independently at RP genes, illustrating the extreme adaptability and flexibility of transcriptional regulatory networks.}, author = {Hogues, Herve and Lavoie, Hugo and Sellam, Adnane and Mangos, Maria and Roemer, Terry and Purisima, Enrico and Nantel, Andre and Whiteway, Malcolm }, citeulike-article-id = {2566542}, doi = {http://dx.doi.org/10.1016/j.molcel.2008.02.006}, journal = {Molecular Cell}, keywords = {evolution, regulation, substitution, transcription}, month = {March}, number = {5}, pages = {552--562}, posted-at = {2008-03-20 13:26:22}, priority = {2}, title = {Transcription Factor Substitution during the Evolution of Fungal Ribosome Regulation}, url = {http://dx.doi.org/10.1016/j.molcel.2008.02.006}, volume = {29}, year = {2008} }

TY - JOUR ID - citeulike:2566542 L3 - citeulike-article-id:2566542 TI - Transcription Factor Substitution during the Evolution of Fungal Ribosome Regulation JF - Molecular Cell VL - 29 IS - 5 SP - 552 EP - 562 N2 - Summary Coordinated ribosomal protein (RP) gene expression is crucial for cellular viability, but the transcriptional network controlling this regulon has only been well characterized in the yeast Saccharomyces cerevisiae. We have used whole-genome transcriptional and location profiling to establish that, in Candida albicans, the RP regulon is controlled by the Myb domain protein Tbf1 working in conjunction with Cbf1. These two factors bind both the promoters of RP genes and the rDNA locus; Tbf1 activates transcription at these loci and is essential. Orthologs of Tbf1 bind TTAGGG telomeric repeats in most eukaryotes, and TTAGGG cis-elements are present upstream of RP genes in plants and fungi, suggesting that Tbf1 was involved in both functions in ancestral eukaryotes. In all Hemiascomycetes, Rap1 substituted Tbf1 at telomeres and, in the S. cerevisiae lineage, this substitution also occurred independently at RP genes, illustrating the extreme adaptability and flexibility of transcriptional regulatory networks. KW - evolution KW - regulation KW - substitution KW - transcription AU - Hogues, Herve AU - Lavoie, Hugo AU - Sellam, Adnane AU - Mangos, Maria AU - Roemer, Terry AU - Purisima, Enrico AU - Nantel, Andre AU - Whiteway, Malcolm PY - 2008/03/14/ UR - http://dx.doi.org/10.1016/j.molcel.2008.02.006 ER -