A Metabolic Throttle Regulates the Epigenetic State of rDNA

by: Ingrid Grummt, Andreas G Ladurner

Cell, Vol. 133, No. 4. (16 May 2008), pp. 577-580.

View FullText article

DOI, Pubmed, Hubmed, ScienceDirect

Reviews [Write a review of this article]

There are no reviews of this article

Find related articles from these CiteULike users

slevy03, zhlei

Find related articles with these CiteULike tags

aging, epigenetics, rdna, review, sirt1, sirtuin

Abstract

The synthesis of ribosomal RNA (rRNA) is carefully tuned to match nutritional conditions. In this issue, Murayama et al. (2008) describe a mechanism that couples the energy status of the cell to heterochromatin formation and silencing of rRNA genes. They show that an altered NAD+/NADH ratio in response to glucose starvation regulates the silencing activity of eNoSC, a complex consisting of the NAD+-dependent histone deacetylase SIRT1, the histone methyltransferase SUV39H1, and a new protein called nucleomethylin (NML). These results suggest a mechanism that links cell physiology to rDNA silencing, which in turn is a prerequisite for nucleolar integrity and cell survival.

@article{citeulike:2809469, abstract = {The synthesis of ribosomal RNA (rRNA) is carefully tuned to match nutritional conditions. In this issue, Murayama et al. (2008) describe a mechanism that couples the energy status of the cell to heterochromatin formation and silencing of rRNA genes. They show that an altered NAD+/NADH ratio in response to glucose starvation regulates the silencing activity of eNoSC, a complex consisting of the NAD+-dependent histone deacetylase SIRT1, the histone methyltransferase SUV39H1, and a new protein called nucleomethylin (NML). These results suggest a mechanism that links cell physiology to rDNA silencing, which in turn is a prerequisite for nucleolar integrity and cell survival.}, author = {Grummt, Ingrid and Ladurner, Andreas G. }, citeulike-article-id = {2809469}, doi = {http://dx.doi.org/10.1016/j.cell.2008.04.026}, journal = {Cell}, keywords = {rdna, review, sirt1, sirtuin}, month = {May}, number = {4}, pages = {577--580}, posted-at = {2008-07-02 20:59:30}, priority = {2}, title = {A Metabolic Throttle Regulates the Epigenetic State of rDNA}, url = {http://dx.doi.org/10.1016/j.cell.2008.04.026}, volume = {133}, year = {2008} }

RIS record

TY - JOUR ID - citeulike:2809469 L3 - citeulike-article-id:2809469 TI - A Metabolic Throttle Regulates the Epigenetic State of rDNA JF - Cell VL - 133 IS - 4 SP - 577 EP - 580 N2 - The synthesis of ribosomal RNA (rRNA) is carefully tuned to match nutritional conditions. In this issue, Murayama et al. (2008) describe a mechanism that couples the energy status of the cell to heterochromatin formation and silencing of rRNA genes. They show that an altered NAD+/NADH ratio in response to glucose starvation regulates the silencing activity of eNoSC, a complex consisting of the NAD+-dependent histone deacetylase SIRT1, the histone methyltransferase SUV39H1, and a new protein called nucleomethylin (NML). These results suggest a mechanism that links cell physiology to rDNA silencing, which in turn is a prerequisite for nucleolar integrity and cell survival. KW - rdna KW - review KW - sirt1 KW - sirtuin AU - Grummt, Ingrid AU - Ladurner, Andreas PY - 2008/05/16/ UR - http://dx.doi.org/10.1016/j.cell.2008.04.026 ER -

RIS BibTeX