E2F1-Regulated MicroRNAs Impair TGF[beta]-Dependent Cell-Cycle Arrest and Apoptosis in Gastric Cancer

@article{citeulike:2696704, abstract = {Summary Deregulation of E2F1 activity and resistance to TGF[beta] are hallmarks of gastric cancer. MicroRNAs (miRNAs) are small noncoding RNAs frequently misregulated in human malignancies. Here we provide evidence that the miR-106b-25 cluster, upregulated in a subset of human gastric tumors, is activated by E2F1 in parallel with its host gene, Mcm7. In turn, miR-106b and miR-93 regulate E2F1 expression, establishing a miRNA-directed negative feedback loop. Furthermore, upregulation of these miRNAs impairs the TGF[beta] tumor suppressor pathway, interfering with the expression of CDKN1A (p21Waf1/Cip1) and BCL2L11 (Bim). Together, these results suggest that the miR-106b-25 cluster is involved in E2F1 posttranscriptional regulation and may play a key role in the development of TGF[beta] resistance in gastric cancer.}, author = {Petrocca, Fabio and Visone, Rosa and Onelli, Mariadele R. and Shah, Manisha H. and Nicoloso, Milena S. and de Martino, Ivana and Iliopoulos, Dimitrios and Pilozzi, Emanuela and Liu, Chang-Gong and Negrini, Massimo and Cavazzini, Luigi and Volinia, Stefano and Alder, Hansjuerg and Ruco, Luigi P. and Baldassarre, Gustavo and Croce, Carlo M. and Vecchione, Andrea }, citeulike-article-id = {2696704}, doi = {http://dx.doi.org/10.1016/j.ccr.2008.02.013}, journal = {Cancer Cell}, keywords = {mirna}, month = {March}, number = {3}, pages = {272--286}, posted-at = {2008-04-21 15:13:41}, priority = {2}, title = {E2F1-Regulated MicroRNAs Impair TGF[beta]-Dependent Cell-Cycle Arrest and Apoptosis in Gastric Cancer}, url = {http://dx.doi.org/10.1016/j.ccr.2008.02.013}, volume = {13}, year = {2008} }

TY - JOUR ID - citeulike:2696704 L3 - citeulike-article-id:2696704 N2 - Summary Deregulation of E2F1 activity and resistance to TGF[beta] are hallmarks of gastric cancer. MicroRNAs (miRNAs) are small noncoding RNAs frequently misregulated in human malignancies. Here we provide evidence that the miR-106b-25 cluster, upregulated in a subset of human gastric tumors, is activated by E2F1 in parallel with its host gene, Mcm7. In turn, miR-106b and miR-93 regulate E2F1 expression, establishing a miRNA-directed negative feedback loop. Furthermore, upregulation of these miRNAs impairs the TGF[beta] tumor suppressor pathway, interfering with the expression of CDKN1A (p21Waf1/Cip1) and BCL2L11 (Bim). Together, these results suggest that the miR-106b-25 cluster is involved in E2F1 posttranscriptional regulation and may play a key role in the development of TGF[beta] resistance in gastric cancer. IS - 3 JF - Cancer Cell EP - 286 TI - E2F1-Regulated MicroRNAs Impair TGF[beta]-Dependent Cell-Cycle Arrest and Apoptosis in Gastric Cancer VL - 13 SP - 272 KW - mirna AU - Petrocca, Fabio AU - Visone, Rosa AU - Onelli, Mariadele AU - Shah, Manisha AU - Nicoloso, Milena AU - de Martino, Ivana AU - Iliopoulos, Dimitrios AU - Pilozzi, Emanuela AU - Liu, Chang-Gong AU - Negrini, Massimo AU - Cavazzini, Luigi AU - Volinia, Stefano AU - Alder, Hansjuerg AU - Ruco, Luigi AU - Baldassarre, Gustavo AU - Croce, Carlo AU - Vecchione, Andrea PY - 2008/03/11/ UR - http://dx.doi.org/10.1016/j.ccr.2008.02.013 ER -