Sirtuins in aging and age-related disease.

by: VD Longo, BK Kennedy

Cell, Vol. 126, No. 2. (28 July 2006), pp. 257-268.

View FullText article

DOI, Pubmed, Hubmed

Reviews [Write a review of this article]

There are no reviews of this article

Find related articles from these CiteULike users

zhlei

Find related articles with these CiteULike tags

aging, cancer, sirt1, sirtuin

Abstract

Sirtuins have been the focus of intense scrutiny since the discovery of Sir2 as a yeast longevity factor. Functioning as either deacetylases or ADP ribosylases, Sirtuins are regulated by the cofactor NAD and thus may serve as sensors of the metabolic state of the cell and organism. Here we examine the roles of Sirtuins in diverse eukaryotic species, with special emphasis on their links to aging and age-related diseases including cancer, diabetes, and neurodegenerative disorders.

@article{citeulike:2642857, abstract = {Sirtuins have been the focus of intense scrutiny since the discovery of Sir2 as a yeast longevity factor. Functioning as either deacetylases or ADP ribosylases, Sirtuins are regulated by the cofactor NAD and thus may serve as sensors of the metabolic state of the cell and organism. Here we examine the roles of Sirtuins in diverse eukaryotic species, with special emphasis on their links to aging and age-related diseases including cancer, diabetes, and neurodegenerative disorders.}, address = {Department of Molecular and Computational Biology, Andrus Gerontology Center, University of Southern California, Los Angeles, CA 90089, USA. vlongo@usc.edu}, author = {Longo, V. D. and Kennedy, B. K. }, citeulike-article-id = {2642857}, doi = {http://dx.doi.org/10.1016/j.cell.2006.07.002}, issn = {0092-8674}, journal = {Cell}, keywords = {aging, cancer, sirt1, sirtuin}, month = {July}, number = {2}, pages = {257--268}, posted-at = {2008-04-08 22:24:32}, priority = {2}, title = {Sirtuins in aging and age-related disease.}, url = {http://dx.doi.org/10.1016/j.cell.2006.07.002}, volume = {126}, year = {2006} }

RIS record

TY - JOUR ID - citeulike:2642857 L3 - citeulike-article-id:2642857 N2 - Sirtuins have been the focus of intense scrutiny since the discovery of Sir2 as a yeast longevity factor. Functioning as either deacetylases or ADP ribosylases, Sirtuins are regulated by the cofactor NAD and thus may serve as sensors of the metabolic state of the cell and organism. Here we examine the roles of Sirtuins in diverse eukaryotic species, with special emphasis on their links to aging and age-related diseases including cancer, diabetes, and neurodegenerative disorders. IS - 2 JF - Cell SN - 0092-8674 AD - Department of Molecular and Computational Biology, Andrus Gerontology Center, University of Southern California, Los Angeles, CA 90089, USA. vlongo@usc.edu EP - 268 TI - Sirtuins in aging and age-related disease. VL - 126 SP - 257 KW - aging KW - cancer KW - sirt1 KW - sirtuin AU - Longo, VD AU - Kennedy, BK PY - 2006/07/28/ UR - http://dx.doi.org/10.1016/j.cell.2006.07.002 ER -

RIS BibTeX