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PHLPPing It off: Phosphatases Get in the AktMolecular Cell, Vol. 25, No. 6. (23 March 2007), pp. 798-800.
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AbstractThree Akt isoforms differentially control cell survival, growth, proliferation, metabolism, and motility. In this issue of Molecular Cell, Brognard et al. (2007) report that two PHLPP phosphatases specifically downregulate the Akts to control the activity of isoform-specific substrates.
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