Mitochondria, oxidants, and aging.

@article{citeulike:2607712, abstract = {The free radical theory of aging postulates that the production of intracellular reactive oxygen species is the major determinant of life span. Numerous cell culture, invertebrate, and mammalian models exist that lend support to this half-century-old hypothesis. Here we review the evidence that both supports and conflicts with the free radical theory and examine the growing link between mitochondrial metabolism, oxidant formation, and the biology of aging.}, address = {Laboratory of Cardiac Energetics, National Institutes of Health, Bethesda, Maryland 20892, USA.}, author = {Balaban, R. S. and Nemoto, S. and Finkel, T. }, citeulike-article-id = {2607712}, doi = {http://dx.doi.org/10.1016/j.cell.2005.02.001}, issn = {0092-8674}, journal = {Cell}, keywords = {aging, cancer, mitochondria, review, ros}, month = {February}, number = {4}, pages = {483--495}, posted-at = {2008-03-28 15:29:48}, priority = {2}, title = {Mitochondria, oxidants, and aging.}, url = {http://dx.doi.org/10.1016/j.cell.2005.02.001}, volume = {120}, year = {2005} }

TY - JOUR ID - citeulike:2607712 L3 - citeulike-article-id:2607712 N2 - The free radical theory of aging postulates that the production of intracellular reactive oxygen species is the major determinant of life span. Numerous cell culture, invertebrate, and mammalian models exist that lend support to this half-century-old hypothesis. Here we review the evidence that both supports and conflicts with the free radical theory and examine the growing link between mitochondrial metabolism, oxidant formation, and the biology of aging. IS - 4 JF - Cell SN - 0092-8674 AD - Laboratory of Cardiac Energetics, National Institutes of Health, Bethesda, Maryland 20892, USA. EP - 495 TI - Mitochondria, oxidants, and aging. VL - 120 SP - 483 KW - aging KW - cancer KW - mitochondria KW - review KW - ros AU - Balaban, RS AU - Nemoto, S AU - Finkel, T PY - 2005/02/25/ UR - http://dx.doi.org/10.1016/j.cell.2005.02.001 ER -