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Hop1 and the meiotic DNA-damage response.

by: N Hunter
Cell, Vol. 132, No. 5. (7 March 2008), pp. 731-732.


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During the DNA-damage response, adaptor proteins mediate signaling between the PI3K-like sensor kinases, ATM and ATR, and serine/threonine effector kinases. Carballo et al. (2008) now show that the chromosomal protein Hop1 mediates PI3K-like kinase signaling during the repair of DNA double-strand breaks (DSBs) in meiosis.


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