Regulators of IAP function: coming to grips with the grim reaper.

by: A Bergmann, AY Yang, M Srivastava

Curr Opin Cell Biol, Vol. 15, No. 6. (December 2003), pp. 717-724.

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Abstract

Inhibitor of apoptosis proteins (IAPs) are a conserved class of proteins that control apoptosis in both vertebrates and invertebrates. They exert their anti-apoptotic function through inhibition of caspases, the principal executioners of apoptotic cell death. Recent advances in vertebrates and Drosophila have demonstrated that IAPs use ubiquitin conjugation to control the stability, and thus the activity, of select target proteins. The Drosophila IAP1 gene is an instructive example: it employs at least two distinct ubiquitin-dependent mechanisms of protein destruction. The apoptosis-inducing genes grim, reaper and hid modulate these mechanisms, and determine the outcome.

@article{citeulike:249095, abstract = {Inhibitor of apoptosis proteins (IAPs) are a conserved class of proteins that control apoptosis in both vertebrates and invertebrates. They exert their anti-apoptotic function through inhibition of caspases, the principal executioners of apoptotic cell death. Recent advances in vertebrates and Drosophila have demonstrated that IAPs use ubiquitin conjugation to control the stability, and thus the activity, of select target proteins. The Drosophila IAP1 gene is an instructive example: it employs at least two distinct ubiquitin-dependent mechanisms of protein destruction. The apoptosis-inducing genes grim, reaper and hid modulate these mechanisms, and determine the outcome.}, address = {The University of Texas MD Anderson Cancer Center, Department of Biochemistry \& Molecular Biology, Unit 117, 1515 Holcombe Blvd, Houston, TX 77030, USA. andreas@bergman.net}, author = {Bergmann, A. and Yang, A. Y. and Srivastava, M. }, citeulike-article-id = {249095}, issn = {0955-0674}, journal = {Curr Opin Cell Biol}, keywords = {apoptosis, review}, month = {December}, number = {6}, pages = {717--724}, posted-at = {2005-07-08 02:14:50}, priority = {4}, title = {Regulators of IAP function: coming to grips with the grim reaper.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/14644196}, volume = {15}, year = {2003} }

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TY - JOUR ID - citeulike:249095 L3 - citeulike-article-id:249095 N2 - Inhibitor of apoptosis proteins (IAPs) are a conserved class of proteins that control apoptosis in both vertebrates and invertebrates. They exert their anti-apoptotic function through inhibition of caspases, the principal executioners of apoptotic cell death. Recent advances in vertebrates and Drosophila have demonstrated that IAPs use ubiquitin conjugation to control the stability, and thus the activity, of select target proteins. The Drosophila IAP1 gene is an instructive example: it employs at least two distinct ubiquitin-dependent mechanisms of protein destruction. The apoptosis-inducing genes grim, reaper and hid modulate these mechanisms, and determine the outcome. IS - 6 JF - Curr Opin Cell Biol SN - 0955-0674 AD - The University of Texas MD Anderson Cancer Center, Department of Biochemistry & Molecular Biology, Unit 117, 1515 Holcombe Blvd, Houston, TX 77030, USA. andreas@bergman.net EP - 724 TI - Regulators of IAP function: coming to grips with the grim reaper. VL - 15 SP - 717 KW - apoptosis KW - review AU - Bergmann, A AU - Yang, AY AU - Srivastava, M PY - 2003/12// UR - http://view.ncbi.nlm.nih.gov/pubmed/14644196 ER -

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