Cell death: critical control points.

by: NN Danial, SJ Korsmeyer

Cell, Vol. 116, No. 2. (23 January 2004), pp. 205-219.

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Abstract

Programmed cell death is a distinct genetic and biochemical pathway essential to metazoans. An intact death pathway is required for successful embryonic development and the maintenance of normal tissue homeostasis. Apoptosis has proven to be tightly interwoven with other essential cell pathways. The identification of critical control points in the cell death pathway has yielded fundamental insights for basic biology, as well as provided rational targets for new therapeutics.

@article{citeulike:249094, abstract = {Programmed cell death is a distinct genetic and biochemical pathway essential to metazoans. An intact death pathway is required for successful embryonic development and the maintenance of normal tissue homeostasis. Apoptosis has proven to be tightly interwoven with other essential cell pathways. The identification of critical control points in the cell death pathway has yielded fundamental insights for basic biology, as well as provided rational targets for new therapeutics.}, address = {Howard Hughes Medical Institute, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.}, author = {Danial, N. N. and Korsmeyer, S. J. }, citeulike-article-id = {249094}, issn = {0092-8674}, journal = {Cell}, keywords = {apoptosis, review}, month = {January}, number = {2}, pages = {205--219}, posted-at = {2005-07-08 02:13:59}, priority = {4}, title = {Cell death: critical control points.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/14744432}, volume = {116}, year = {2004} }

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TY - JOUR ID - citeulike:249094 L3 - citeulike-article-id:249094 N2 - Programmed cell death is a distinct genetic and biochemical pathway essential to metazoans. An intact death pathway is required for successful embryonic development and the maintenance of normal tissue homeostasis. Apoptosis has proven to be tightly interwoven with other essential cell pathways. The identification of critical control points in the cell death pathway has yielded fundamental insights for basic biology, as well as provided rational targets for new therapeutics. IS - 2 JF - Cell SN - 0092-8674 AD - Howard Hughes Medical Institute, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA. EP - 219 TI - Cell death: critical control points. VL - 116 SP - 205 KW - apoptosis KW - review AU - Danial, NN AU - Korsmeyer, SJ PY - 2004/01/23/ UR - http://view.ncbi.nlm.nih.gov/pubmed/14744432 ER -

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