Berberine prevents UV-induced MMP-1 and reduction of type I procollagen expression in human dermal fibroblasts.

@article{citeulike:2401232, abstract = {Matrix metalloproteinases (MMPs) induction and type I procollagen reduction in photoaging of the skin due to exposure to ultraviolet (UV) irradiation. Therefore, regulation of these genes has been suggested to be a useful tool to abolish skin aging. In this study, antioxidative plant ingredients used in traditional Chinese medicine, berberine (BBR) was investigated for their capacity to regulate MMP-1 and type I procollagen expression in human dermal fibroblasts. Our results showed that both basal and UV-induced MMP-1 expression was decreased by BBR. On the other hand, type I procollagen expression was dose-dependently increased by it. In addition, UV-induced reduction of type I procollagen expression is recovered by it. Therefore, we suggest that BBR may be a possible candidate for anti-skin aging agent.}, address = {Department of Dermatology, Seoul National University College of Medicine, Seoul, Republic of Korea; Laboratory of Cutaneous Aging Research, Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea; Institute of Dermatological Science, Medical Research Center, Seoul National University, Seoul, Republic of Korea.}, author = {Kim, Sangmin and Chung, Jin Ho H. }, citeulike-article-id = {2401232}, doi = {http://dx.doi.org/10.1016/j.phymed.2007.11.004}, issn = {0944-7113}, journal = {Phytomedicine}, keywords = {aging}, month = {December}, posted-at = {2008-02-20 02:47:50}, priority = {2}, title = {Berberine prevents UV-induced MMP-1 and reduction of type I procollagen expression in human dermal fibroblasts.}, url = {http://dx.doi.org/10.1016/j.phymed.2007.11.004}, year = {2007} }

TY - JOUR ID - citeulike:2401232 L3 - citeulike-article-id:2401232 N2 - Matrix metalloproteinases (MMPs) induction and type I procollagen reduction in photoaging of the skin due to exposure to ultraviolet (UV) irradiation. Therefore, regulation of these genes has been suggested to be a useful tool to abolish skin aging. In this study, antioxidative plant ingredients used in traditional Chinese medicine, berberine (BBR) was investigated for their capacity to regulate MMP-1 and type I procollagen expression in human dermal fibroblasts. Our results showed that both basal and UV-induced MMP-1 expression was decreased by BBR. On the other hand, type I procollagen expression was dose-dependently increased by it. In addition, UV-induced reduction of type I procollagen expression is recovered by it. Therefore, we suggest that BBR may be a possible candidate for anti-skin aging agent. JF - Phytomedicine SN - 0944-7113 AD - Department of Dermatology, Seoul National University College of Medicine, Seoul, Republic of Korea; Laboratory of Cutaneous Aging Research, Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea; Institute of Dermatological Science, Medical Research Center, Seoul National University, Seoul, Republic of Korea. TI - Berberine prevents UV-induced MMP-1 and reduction of type I procollagen expression in human dermal fibroblasts. KW - aging AU - Kim, Sangmin AU - Chung, Jin Ho PY - 2007/12/26/ UR - http://dx.doi.org/10.1016/j.phymed.2007.11.004 ER -