Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS.

@article{citeulike:2366882, abstract = {Calorie restriction extends life span in organisms ranging from yeast to mammals. Here, we report that calorie restriction for either 3 or 12 months induced endothelial nitric oxide synthase (eNOS) expression and 3',5'-cyclic guanosine monophosphate formation in various tissues of male mice. This was accompanied by mitochondrial biogenesis, with increased oxygen consumption and adenosine triphosphate production, and an enhanced expression of sirtuin 1. These effects were strongly attenuated in eNOS null-mutant mice. Thus, nitric oxide plays a fundamental role in the processes induced by calorie restriction and may be involved in the extension of life span in mammals.}, address = {Integrated Laboratories Network, Department of Preclinical Sciences, Luigi Sacco Hospital, Milan University, 20157 Milan, Italy. enzo.nisoli@unimi.it}, author = {Nisoli, E. and Tonello, C. and Cardile, A. and Cozzi, V. and Bracale, R. and Tedesco, L. and Falcone, S. and Valerio, A. and Cantoni, O. and Clementi, E. and Moncada, S. and Carruba, M. O. }, citeulike-article-id = {2366882}, doi = {http://dx.doi.org/10.1126/science.1117728}, issn = {1095-9203}, journal = {Science}, keywords = {calorie\_restriction, cr, enos, mitochondria, sirt1}, month = {October}, number = {5746}, pages = {314--317}, posted-at = {2008-02-12 19:13:46}, priority = {2}, title = {Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS.}, url = {http://dx.doi.org/10.1126/science.1117728}, volume = {310}, year = {2005} }

TY - JOUR ID - citeulike:2366882 L3 - citeulike-article-id:2366882 N2 - Calorie restriction extends life span in organisms ranging from yeast to mammals. Here, we report that calorie restriction for either 3 or 12 months induced endothelial nitric oxide synthase (eNOS) expression and 3',5'-cyclic guanosine monophosphate formation in various tissues of male mice. This was accompanied by mitochondrial biogenesis, with increased oxygen consumption and adenosine triphosphate production, and an enhanced expression of sirtuin 1. These effects were strongly attenuated in eNOS null-mutant mice. Thus, nitric oxide plays a fundamental role in the processes induced by calorie restriction and may be involved in the extension of life span in mammals. IS - 5746 JF - Science SN - 1095-9203 AD - Integrated Laboratories Network, Department of Preclinical Sciences, Luigi Sacco Hospital, Milan University, 20157 Milan, Italy. enzo.nisoli@unimi.it EP - 317 TI - Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS. VL - 310 SP - 314 KW - calorie_restriction KW - cr KW - enos KW - mitochondria KW - sirt1 AU - Nisoli, E AU - Tonello, C AU - Cardile, A AU - Cozzi, V AU - Bracale, R AU - Tedesco, L AU - Falcone, S AU - Valerio, A AU - Cantoni, O AU - Clementi, E AU - Moncada, S AU - Carruba, MO PY - 2005/10/14/ UR - http://dx.doi.org/10.1126/science.1117728 ER -