Plant responses to ethylene gas are mediated by SCF(EBF1/EBF2)-dependent proteolysis of EIN3 transcription factor.

@article{citeulike:235139, abstract = {Plants use ethylene gas as a signal to regulate myriad developmental processes and stress responses. The Arabidopsis EIN3 protein is a key transcription factor mediating ethylene-regulated gene expression and morphological responses. Here, we report that EIN3 protein levels rapidly increase in response to ethylene and this response requires several ethylene-signaling pathway components including the ethylene receptors (ETR1 and EIN4), CTR1, EIN2, EIN5, and EIN6. In the absence of ethylene, EIN3 is quickly degraded through a ubiquitin/proteasome pathway mediated by two F box proteins, EBF1 and EBF2. Plants containing mutations in either gene show enhanced ethylene response by stabilizing EIN3, whereas efb1 efb2 double mutants show constitutive ethylene phenotypes. Plants overexpressing either F box gene display ethylene insensitivity and destabilization of EIN3 protein. These results reveal that a ubiquitin/proteasome pathway negatively regulates ethylene responses by targeting EIN3 for degradation, and pinpoint EIN3 regulation as the key step in the response to ethylene.}, address = {Plant Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.}, author = {Guo, H. and Ecker, J. R. }, citeulike-article-id = {235139}, issn = {0092-8674}, journal = {Cell}, keywords = {arabidopsis, plant, proteasome}, month = {December}, number = {6}, pages = {667--677}, posted-at = {2005-06-23 02:49:09}, priority = {2}, title = {Plant responses to ethylene gas are mediated by SCF(EBF1/EBF2)-dependent proteolysis of EIN3 transcription factor.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/14675532}, volume = {115}, year = {2003} }

TY - JOUR ID - citeulike:235139 L3 - citeulike-article-id:235139 N2 - Plants use ethylene gas as a signal to regulate myriad developmental processes and stress responses. The Arabidopsis EIN3 protein is a key transcription factor mediating ethylene-regulated gene expression and morphological responses. Here, we report that EIN3 protein levels rapidly increase in response to ethylene and this response requires several ethylene-signaling pathway components including the ethylene receptors (ETR1 and EIN4), CTR1, EIN2, EIN5, and EIN6. In the absence of ethylene, EIN3 is quickly degraded through a ubiquitin/proteasome pathway mediated by two F box proteins, EBF1 and EBF2. Plants containing mutations in either gene show enhanced ethylene response by stabilizing EIN3, whereas efb1 efb2 double mutants show constitutive ethylene phenotypes. Plants overexpressing either F box gene display ethylene insensitivity and destabilization of EIN3 protein. These results reveal that a ubiquitin/proteasome pathway negatively regulates ethylene responses by targeting EIN3 for degradation, and pinpoint EIN3 regulation as the key step in the response to ethylene. IS - 6 JF - Cell SN - 0092-8674 AD - Plant Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA. EP - 677 TI - Plant responses to ethylene gas are mediated by SCF(EBF1/EBF2)-dependent proteolysis of EIN3 transcription factor. VL - 115 SP - 667 KW - arabidopsis KW - plant KW - proteasome AU - Guo, H AU - Ecker, JR PY - 2003/12/12/ UR - http://view.ncbi.nlm.nih.gov/pubmed/14675532 ER -