H3K27 Demethylases, at Long Last

@article{citeulike:1947476, abstract = {Methylation of lysine 27 on histone H3 (H3K27me) by the Polycomb complex (PRC2) proteins is associated with gene silencing in many developmental processes. A cluster of recent papers ([Agger et al., 2007], [De Santa et al., 2007], [Lan et al., 2007] and [Lee et al., 2007]) identify the JmjC-domain proteins UTX and JMJD3 as H3K27-specific demethylases that remove this methyl mark, enabling the activation of genes involved in animal body patterning and the inflammatory response.}, author = {Swigut, Tomek and Wysocka, Joanna }, citeulike-article-id = {1947476}, doi = {http://dx.doi.org/10.1016/j.cell.2007.09.026}, journal = {Cell}, keywords = {demethylation, histone, methylation, review}, month = {October}, number = {1}, pages = {29--32}, posted-at = {2007-11-21 00:12:20}, priority = {4}, title = {H3K27 Demethylases, at Long Last}, url = {http://dx.doi.org/10.1016/j.cell.2007.09.026}, volume = {131}, year = {2007} }

TY - JOUR ID - citeulike:1947476 L3 - citeulike-article-id:1947476 N2 - Methylation of lysine 27 on histone H3 (H3K27me) by the Polycomb complex (PRC2) proteins is associated with gene silencing in many developmental processes. A cluster of recent papers ([Agger et al., 2007], [De Santa et al., 2007], [Lan et al., 2007] and [Lee et al., 2007]) identify the JmjC-domain proteins UTX and JMJD3 as H3K27-specific demethylases that remove this methyl mark, enabling the activation of genes involved in animal body patterning and the inflammatory response. IS - 1 JF - Cell EP - 32 TI - H3K27 Demethylases, at Long Last VL - 131 SP - 29 KW - demethylation KW - histone KW - methylation KW - review AU - Swigut, Tomek AU - Wysocka, Joanna PY - 2007/10/05/ UR - http://dx.doi.org/10.1016/j.cell.2007.09.026 ER -