Sirtuins: critical regulators at the crossroads between cancer and aging.

@article{citeulike:1853967, abstract = {Sirtuins (SIRTs 1-7), or class III histone deacetylases (HDACs), are protein deacetylases/ADP ribosyltransferases that target a wide range of cellular proteins in the nucleus, cytoplasm, and mitochondria for post-translational modification by acetylation (SIRT1, -2, -3 and -5) or ADP ribosylation (SIRT4 and -6). The orthologs of sirtuins in lower organisms play a critical role in regulating lifespan. As cancer is a disease of aging, we discuss the growing implications of the sirtuins in protecting against cancer development. Sirtuins regulate the cellular responses to stress and ensure that damaged DNA is not propagated and that mutations do not accumulate. SIRT1 also promotes replicative senescence under conditions of chronic stress. By participating in the stress response to genomic insults, sirtuins are thought to protect against cancer, but they are also emerging as direct participants in the growth of some cancers. Here, we review the growing implications of sirtuins both in cancer prevention and as specific and novel cancer therapeutic targets.}, address = {Gladstone Institute of Virology and Immunology, University of California, San Francisco, CA, USA.}, author = {Saunders, L. R. and Verdin, E. }, citeulike-article-id = {1853967}, doi = {http://dx.doi.org/10.1038/sj.onc.1210616}, issn = {0950-9232}, journal = {Oncogene}, keywords = {aging, cancer, review, sirtuin}, month = {August}, number = {37}, pages = {5489--5504}, posted-at = {2007-11-02 02:20:58}, priority = {2}, title = {Sirtuins: critical regulators at the crossroads between cancer and aging.}, url = {http://dx.doi.org/10.1038/sj.onc.1210616}, volume = {26}, year = {2007} }

TY - JOUR ID - citeulike:1853967 L3 - citeulike-article-id:1853967 N2 - Sirtuins (SIRTs 1-7), or class III histone deacetylases (HDACs), are protein deacetylases/ADP ribosyltransferases that target a wide range of cellular proteins in the nucleus, cytoplasm, and mitochondria for post-translational modification by acetylation (SIRT1, -2, -3 and -5) or ADP ribosylation (SIRT4 and -6). The orthologs of sirtuins in lower organisms play a critical role in regulating lifespan. As cancer is a disease of aging, we discuss the growing implications of the sirtuins in protecting against cancer development. Sirtuins regulate the cellular responses to stress and ensure that damaged DNA is not propagated and that mutations do not accumulate. SIRT1 also promotes replicative senescence under conditions of chronic stress. By participating in the stress response to genomic insults, sirtuins are thought to protect against cancer, but they are also emerging as direct participants in the growth of some cancers. Here, we review the growing implications of sirtuins both in cancer prevention and as specific and novel cancer therapeutic targets. IS - 37 JF - Oncogene SN - 0950-9232 AD - Gladstone Institute of Virology and Immunology, University of California, San Francisco, CA, USA. EP - 5504 TI - Sirtuins: critical regulators at the crossroads between cancer and aging. VL - 26 SP - 5489 KW - aging KW - cancer KW - review KW - sirtuin AU - Saunders, LR AU - Verdin, E PY - 2007/08/13/ UR - http://dx.doi.org/10.1038/sj.onc.1210616 ER -