Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1[alpha]

@article{citeulike:1768854, abstract = {Summary Diminished mitochondrial oxidative phosphorylation and aerobic capacity are associated with reduced longevity. We tested whether resveratrol (RSV), which is known to extend lifespan, impacts mitochondrial function and metabolic homeostasis. Treatment of mice with RSV significantly increased their aerobic capacity, as evidenced by their increased running time and consumption of oxygen in muscle fibers. RSV's effects were associated with an induction of genes for oxidative phosphorylation and mitochondrial biogenesis and were largely explained by an RSV-mediated decrease in PGC-1[alpha] acetylation and an increase in PGC-1[alpha] activity. This mechanism is consistent with RSV being a known activator of the protein deacetylase, SIRT1, and by the lack of effect of RSV in SIRT1-/- MEFs. Importantly, RSV treatment protected mice against diet-induced-obesity and insulin resistance. These pharmacological effects of RSV combined with the association of three Sirt1 SNPs and energy homeostasis in Finnish subjects implicates SIRT1 as a key regulator of energy and metabolic homeostasis.}, author = {Lagouge, Marie and Argmann, Carmen and Gerhart-Hines, Zachary and Meziane, Hamid and Lerin, Carles and Daussin, Frederic and Messadeq, Nadia and Milne, Jill and Lambert, Philip and Elliott, Peter and Geny, Bernard and Laakso, Markku and Puigserver, Pere and Auwerx, Johan }, citeulike-article-id = {1768854}, doi = {http://dx.doi.org/10.1016/j.cell.2006.11.013}, journal = {Cell}, keywords = {aging, resveratrol, sirt1}, month = {December}, number = {6}, pages = {1109--1122}, posted-at = {2007-11-30 22:43:37}, priority = {2}, title = {Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1[alpha]}, url = {http://dx.doi.org/10.1016/j.cell.2006.11.013}, volume = {127}, year = {2006} }

TY - JOUR ID - citeulike:1768854 L3 - citeulike-article-id:1768854 N2 - Summary Diminished mitochondrial oxidative phosphorylation and aerobic capacity are associated with reduced longevity. We tested whether resveratrol (RSV), which is known to extend lifespan, impacts mitochondrial function and metabolic homeostasis. Treatment of mice with RSV significantly increased their aerobic capacity, as evidenced by their increased running time and consumption of oxygen in muscle fibers. RSV's effects were associated with an induction of genes for oxidative phosphorylation and mitochondrial biogenesis and were largely explained by an RSV-mediated decrease in PGC-1[alpha] acetylation and an increase in PGC-1[alpha] activity. This mechanism is consistent with RSV being a known activator of the protein deacetylase, SIRT1, and by the lack of effect of RSV in SIRT1-/- MEFs. Importantly, RSV treatment protected mice against diet-induced-obesity and insulin resistance. These pharmacological effects of RSV combined with the association of three Sirt1 SNPs and energy homeostasis in Finnish subjects implicates SIRT1 as a key regulator of energy and metabolic homeostasis. IS - 6 JF - Cell EP - 1122 TI - Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1[alpha] VL - 127 SP - 1109 KW - aging KW - resveratrol KW - sirt1 AU - Lagouge, Marie AU - Argmann, Carmen AU - Gerhart-Hines, Zachary AU - Meziane, Hamid AU - Lerin, Carles AU - Daussin, Frederic AU - Messadeq, Nadia AU - Milne, Jill AU - Lambert, Philip AU - Elliott, Peter AU - Geny, Bernard AU - Laakso, Markku AU - Puigserver, Pere AU - Auwerx, Johan PY - 2006/12/15/ UR - http://dx.doi.org/10.1016/j.cell.2006.11.013 ER -