Mammalian sirtuins--emerging roles in physiology, aging, and calorie restriction

@article{citeulike:1667156, abstract = {Sir2 is an NAD-dependent deacetylase that connects metabolism with longevity in yeast, worms and flies. Mammals contain seven homologs of yeast Sir2, SIRT1-7. Here, we review recent findings demonstrating the role of these mammalian sirtuins as regulators of physiology, calorie restriction, and aging. The current findings sharpen our understanding of sirtuins as potential pharmacological targets to treat the major diseases of aging. 10.1101/gad.1467506}, author = {Haigis, Marcia C. and Guarente, Leonard P. }, citeulike-article-id = {1667156}, doi = {http://dx.doi.org/10.1101/gad.1467506}, journal = {Genes Dev.}, keywords = {aging, longevity, mammal, mammalian, sir2, sirtuin}, month = {November}, number = {21}, pages = {2913--2921}, posted-at = {2007-09-17 21:27:14}, priority = {2}, title = {Mammalian sirtuins--emerging roles in physiology, aging, and calorie restriction}, url = {http://dx.doi.org/10.1101/gad.1467506}, volume = {20}, year = {2006} }

TY - JOUR ID - citeulike:1667156 L3 - citeulike-article-id:1667156 N2 - Sir2 is an NAD-dependent deacetylase that connects metabolism with longevity in yeast, worms and flies. Mammals contain seven homologs of yeast Sir2, SIRT1-7. Here, we review recent findings demonstrating the role of these mammalian sirtuins as regulators of physiology, calorie restriction, and aging. The current findings sharpen our understanding of sirtuins as potential pharmacological targets to treat the major diseases of aging. 10.1101/gad.1467506 IS - 21 JF - Genes Dev. EP - 2921 TI - Mammalian sirtuins--emerging roles in physiology, aging, and calorie restriction VL - 20 SP - 2913 KW - aging KW - longevity KW - mammal KW - mammalian KW - sir2 KW - sirtuin AU - Haigis, Marcia AU - Guarente, Leonard PY - 2006/11/01/ UR - http://dx.doi.org/10.1101/gad.1467506 ER -