AKT/PKB signaling: navigating downstream.

by: BD Manning, LC Cantley

Cell, Vol. 129, No. 7. (29 June 2007), pp. 1261-1274.

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Abstract

The serine/threonine kinase Akt, also known as protein kinase B (PKB), is a central node in cell signaling downstream of growth factors, cytokines, and other cellular stimuli. Aberrant loss or gain of Akt activation underlies the pathophysiological properties of a variety of complex diseases, including type-2 diabetes and cancer. Here, we review the molecular properties of Akt and the approaches used to characterize its true cellular targets. In addition, we discuss those Akt substrates that are most likely to contribute to the diverse cellular roles of Akt, which include cell survival, growth, proliferation, angiogenesis, metabolism, and migration.

@article{citeulike:1456304, abstract = {The serine/threonine kinase Akt, also known as protein kinase B (PKB), is a central node in cell signaling downstream of growth factors, cytokines, and other cellular stimuli. Aberrant loss or gain of Akt activation underlies the pathophysiological properties of a variety of complex diseases, including type-2 diabetes and cancer. Here, we review the molecular properties of Akt and the approaches used to characterize its true cellular targets. In addition, we discuss those Akt substrates that are most likely to contribute to the diverse cellular roles of Akt, which include cell survival, growth, proliferation, angiogenesis, metabolism, and migration.}, address = {Department of Genetics and Complex Diseases, Harvard School of Public Health, SPH2-117, Boston, MA 02115, USA. bmanning@hsp.harvard.edu}, author = {Manning, B. D. and Cantley, L. C. }, citeulike-article-id = {1456304}, doi = {http://dx.doi.org/10.1016/j.cell.2007.06.009}, issn = {0092-8674}, journal = {Cell}, keywords = {akt, review}, month = {June}, number = {7}, pages = {1261--1274}, posted-at = {2008-04-29 18:21:18}, priority = {2}, title = {AKT/PKB signaling: navigating downstream.}, url = {http://dx.doi.org/10.1016/j.cell.2007.06.009}, volume = {129}, year = {2007} }

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TY - JOUR ID - citeulike:1456304 L3 - citeulike-article-id:1456304 N2 - The serine/threonine kinase Akt, also known as protein kinase B (PKB), is a central node in cell signaling downstream of growth factors, cytokines, and other cellular stimuli. Aberrant loss or gain of Akt activation underlies the pathophysiological properties of a variety of complex diseases, including type-2 diabetes and cancer. Here, we review the molecular properties of Akt and the approaches used to characterize its true cellular targets. In addition, we discuss those Akt substrates that are most likely to contribute to the diverse cellular roles of Akt, which include cell survival, growth, proliferation, angiogenesis, metabolism, and migration. IS - 7 JF - Cell SN - 0092-8674 AD - Department of Genetics and Complex Diseases, Harvard School of Public Health, SPH2-117, Boston, MA 02115, USA. bmanning@hsp.harvard.edu EP - 1274 TI - AKT/PKB signaling: navigating downstream. VL - 129 SP - 1261 KW - akt KW - review AU - Manning, BD AU - Cantley, LC PY - 2007/06/29/ UR - http://dx.doi.org/10.1016/j.cell.2007.06.009 ER -

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