Coordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathways

by: Arnold J Levine, Zhaohui Feng, Tak W Mak, Han You, Shengkan Jin

Genes Dev., Vol. 20, No. 3. (1 February 2006), pp. 267-275.

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Abstract

Over the past 10 years the signal transduction networks for p53, IGF-1-AKT, and TOR pathways have been assembled in worms, flies, and mammals, and their functions elucidated. In the past 1-2 years a number of genes and their proteins have been identified that permit extensive communication and coordination between these pathways. These three pathways are involved in sensing and integrating signals arising from nutrient and growth factor availability, signals from sensory and sexual organs, and intrinsic and extrinsic stress signals. In turn these pathways regulate cell growth, proliferation, and death. These networks are central to our understanding of a variety of physiological and pathological conditions, including cancer, diabetes, and longevity. 10.1101/gad.1363206

@article{citeulike:1452636, abstract = {Over the past 10 years the signal transduction networks for p53, IGF-1-AKT, and TOR pathways have been assembled in worms, flies, and mammals, and their functions elucidated. In the past 1-2 years a number of genes and their proteins have been identified that permit extensive communication and coordination between these pathways. These three pathways are involved in sensing and integrating signals arising from nutrient and growth factor availability, signals from sensory and sexual organs, and intrinsic and extrinsic stress signals. In turn these pathways regulate cell growth, proliferation, and death. These networks are central to our understanding of a variety of physiological and pathological conditions, including cancer, diabetes, and longevity. 10.1101/gad.1363206}, author = {Levine, Arnold J. and Feng, Zhaohui and Mak, Tak W. and You, Han and Jin, Shengkan }, citeulike-article-id = {1452636}, doi = {http://dx.doi.org/10.1101/gad.1363206}, journal = {Genes Dev.}, keywords = {akt, ifg1, p53, review, tor}, month = {February}, number = {3}, pages = {267--275}, posted-at = {2008-01-09 15:24:35}, priority = {2}, title = {Coordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathways}, url = {http://dx.doi.org/10.1101/gad.1363206}, volume = {20}, year = {2006} }

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TY - JOUR ID - citeulike:1452636 L3 - citeulike-article-id:1452636 TI - Coordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathways JF - Genes Dev. VL - 20 IS - 3 SP - 267 EP - 275 N2 - Over the past 10 years the signal transduction networks for p53, IGF-1-AKT, and TOR pathways have been assembled in worms, flies, and mammals, and their functions elucidated. In the past 1-2 years a number of genes and their proteins have been identified that permit extensive communication and coordination between these pathways. These three pathways are involved in sensing and integrating signals arising from nutrient and growth factor availability, signals from sensory and sexual organs, and intrinsic and extrinsic stress signals. In turn these pathways regulate cell growth, proliferation, and death. These networks are central to our understanding of a variety of physiological and pathological conditions, including cancer, diabetes, and longevity. 10.1101/gad.1363206 KW - akt KW - ifg1 KW - p53 KW - review KW - tor AU - Levine, Arnold AU - Feng, Zhaohui AU - Mak, Tak AU - You, Han AU - Jin, Shengkan PY - 2006/02/01/ UR - http://dx.doi.org/10.1101/gad.1363206 ER -

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