Hitchhiking mapping: A population-based fine-mapping strategy for adaptive mutations in Drosophilamelanogaster

@article{citeulike:1919466, abstract = {The identification of genes contributing to the adaptation of local populations is of great biological interest. In an attempt to characterize functionally important differences among African and non-African Drosophila melanogaster populations, we surveyed neutral microsatellite variation in an 850-kb genomic sequence. Three genomic regions were identified that putatively bear an adaptive mutation associated with the habitat expansion of D. melanogaster. A further inspection of two regions by sequence analysis of multiple fragments confirmed the presence of a recent beneficial mutation in the non-African populations. Our study suggests that hitchhiking mapping is a universal approach for the identification of ecologically important mutations. 10.1073/pnas.202336899}, author = {Harr, Bettina and Kauer, Max and Schlotterer, Christian }, citeulike-article-id = {1919466}, doi = {http://dx.doi.org/10.1073/pnas.202336899}, journal = {Proceedings of the National Academy of Sciences}, keywords = {adaptive-radiation, hitchhiking, mapping}, month = {October}, number = {20}, pages = {12949--12954}, posted-at = {2007-11-15 05:53:53}, priority = {2}, title = {Hitchhiking mapping: A population-based fine-mapping strategy for adaptive mutations in Drosophilamelanogaster}, url = {http://dx.doi.org/10.1073/pnas.202336899}, volume = {99}, year = {2002} }

TY - JOUR ID - citeulike:1919466 L3 - citeulike-article-id:1919466 TI - Hitchhiking mapping: A population-based fine-mapping strategy for adaptive mutations in Drosophilamelanogaster JF - Proceedings of the National Academy of Sciences VL - 99 IS - 20 SP - 12949 EP - 12954 N2 - The identification of genes contributing to the adaptation of local populations is of great biological interest. In an attempt to characterize functionally important differences among African and non-African Drosophila melanogaster populations, we surveyed neutral microsatellite variation in an 850-kb genomic sequence. Three genomic regions were identified that putatively bear an adaptive mutation associated with the habitat expansion of D. melanogaster. A further inspection of two regions by sequence analysis of multiple fragments confirmed the presence of a recent beneficial mutation in the non-African populations. Our study suggests that hitchhiking mapping is a universal approach for the identification of ecologically important mutations. 10.1073/pnas.202336899 KW - adaptive-radiation KW - hitchhiking KW - mapping AU - Harr, Bettina AU - Kauer, Max AU - Schlotterer, Christian PY - 2002/10/01/ UR - http://dx.doi.org/10.1073/pnas.202336899 ER -