Endocrine regulation of energy metabolism by the skeleton.

@article{citeulike:2382996, abstract = {The regulation of bone remodeling by an adipocyte-derived hormone implies that bone may exert a feedback control of energy homeostasis. To test this hypothesis we looked for genes expressed in osteoblasts, encoding signaling molecules and affecting energy metabolism. We show here that mice lacking the protein tyrosine phosphatase OST-PTP are hypoglycemic and are protected from obesity and glucose intolerance because of an increase in beta-cell proliferation, insulin secretion, and insulin sensitivity. In contrast, mice lacking the osteoblast-secreted molecule osteocalcin display decreased beta-cell proliferation, glucose intolerance, and insulin resistance. Removing one Osteocalcin allele from OST-PTP-deficient mice corrects their metabolic phenotype. Ex vivo, osteocalcin can stimulate CyclinD1 and Insulin expression in beta-cells and Adiponectin, an insulin-sensitizing adipokine, in adipocytes; in vivo osteocalcin can improve glucose tolerance. By revealing that the skeleton exerts an endocrine regulation of sugar homeostasis this study expands the biological importance of this organ and our understanding of energy metabolism.}, address = {Department of Genetics \& Development, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.}, author = {Lee, N. K. and Sowa, H. and Hinoi, E. and Ferron, M. and Ahn, J. D. and Confavreux, C. and Dacquin, R. and Mee, P. J. and McKee, M. D. and Jung, D. Y. and Zhang, Z. and Kim, J. K. and Mauvais-Jarvis, F. and Ducy, P. and Karsenty, G. }, citeulike-article-id = {2382996}, doi = {http://dx.doi.org/10.1016/j.cell.2007.05.047}, issn = {0092-8674}, journal = {Cell}, keywords = {bone, endocrine, metabolism, sleleton}, month = {August}, number = {3}, pages = {456--469}, posted-at = {2008-02-15 00:12:58}, priority = {4}, title = {Endocrine regulation of energy metabolism by the skeleton.}, url = {http://dx.doi.org/10.1016/j.cell.2007.05.047}, volume = {130}, year = {2007} }

TY - JOUR ID - citeulike:2382996 L3 - citeulike-article-id:2382996 TI - Endocrine regulation of energy metabolism by the skeleton. JF - Cell VL - 130 IS - 3 SP - 456 EP - 469 AD - Department of Genetics & Development, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. SN - 0092-8674 N2 - The regulation of bone remodeling by an adipocyte-derived hormone implies that bone may exert a feedback control of energy homeostasis. To test this hypothesis we looked for genes expressed in osteoblasts, encoding signaling molecules and affecting energy metabolism. We show here that mice lacking the protein tyrosine phosphatase OST-PTP are hypoglycemic and are protected from obesity and glucose intolerance because of an increase in beta-cell proliferation, insulin secretion, and insulin sensitivity. In contrast, mice lacking the osteoblast-secreted molecule osteocalcin display decreased beta-cell proliferation, glucose intolerance, and insulin resistance. Removing one Osteocalcin allele from OST-PTP-deficient mice corrects their metabolic phenotype. Ex vivo, osteocalcin can stimulate CyclinD1 and Insulin expression in beta-cells and Adiponectin, an insulin-sensitizing adipokine, in adipocytes; in vivo osteocalcin can improve glucose tolerance. By revealing that the skeleton exerts an endocrine regulation of sugar homeostasis this study expands the biological importance of this organ and our understanding of energy metabolism. KW - bone KW - endocrine KW - metabolism KW - sleleton AU - Lee, NK AU - Sowa, H AU - Hinoi, E AU - Ferron, M AU - Ahn, JD AU - Confavreux, C AU - Dacquin, R AU - Mee, PJ AU - McKee, MD AU - Jung, DY AU - Zhang, Z AU - Kim, JK AU - Mauvais-Jarvis, F AU - Ducy, P AU - Karsenty, G PY - 2007/08/10/ UR - http://dx.doi.org/10.1016/j.cell.2007.05.047 ER -