Unraveling signalling cascades for the Snail family of transcription factors.

@article{citeulike:1595000, abstract = {During development and carcinogenesis, the gradient of different molecular factors, the availability of corresponding receptors and the interplay between different signalling cascades combine to orchestrate the different stages. A good understanding of both developmental processes and oncogenesis leads to new insights into normal and aberrant regulation, processes that share some mutual key players. In this review, we will focus on the Snail family of transcription factors. These proteins, which share an evolutionarily conserved role in invertebrates and vertebrates, are implicated in several developmental processes, but are involved in carcinogenesis as well. We will highlight the different signalling cascades leading to the expression of Snail and Slug and how these factors are regulated on the transcriptional level. Then we will focus on how these factors execute their functions by repression of the numerous target genes that have been described to date.}, address = {Unit of Molecular and Cellular Oncology, Department for Molecular Biomedical Research, VIB-Ghent University, Technologiepark 927, B-9052 Ghent (Zwijnaarde), Belgium.}, author = {De Craene, B. and van Roy, F. and Berx, G. }, citeulike-article-id = {1595000}, doi = {http://dx.doi.org/10.1016/j.cellsig.2004.10.011}, issn = {0898-6568}, journal = {Cell Signal}, keywords = {signalling, snail}, month = {May}, number = {5}, pages = {535--547}, posted-at = {2008-05-29 16:07:15}, priority = {2}, title = {Unraveling signalling cascades for the Snail family of transcription factors.}, url = {http://dx.doi.org/10.1016/j.cellsig.2004.10.011}, volume = {17}, year = {2005} }

TY - JOUR ID - citeulike:1595000 L3 - citeulike-article-id:1595000 N2 - During development and carcinogenesis, the gradient of different molecular factors, the availability of corresponding receptors and the interplay between different signalling cascades combine to orchestrate the different stages. A good understanding of both developmental processes and oncogenesis leads to new insights into normal and aberrant regulation, processes that share some mutual key players. In this review, we will focus on the Snail family of transcription factors. These proteins, which share an evolutionarily conserved role in invertebrates and vertebrates, are implicated in several developmental processes, but are involved in carcinogenesis as well. We will highlight the different signalling cascades leading to the expression of Snail and Slug and how these factors are regulated on the transcriptional level. Then we will focus on how these factors execute their functions by repression of the numerous target genes that have been described to date. IS - 5 JF - Cell Signal SN - 0898-6568 AD - Unit of Molecular and Cellular Oncology, Department for Molecular Biomedical Research, VIB-Ghent University, Technologiepark 927, B-9052 Ghent (Zwijnaarde), Belgium. EP - 547 TI - Unraveling signalling cascades for the Snail family of transcription factors. VL - 17 SP - 535 KW - signalling KW - snail AU - De Craene, B AU - van Roy, F AU - Berx, G PY - 2005/05// UR - http://dx.doi.org/10.1016/j.cellsig.2004.10.011 ER -