Gene-set approach for expression pattern analysis

by: Dougu Nam, Seon-Young Kim

Brief Bioinform (17 January 2008), bbn001.

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Abstract

Recently developed gene set analysis methods evaluate differential expression patterns of gene groups instead of those of individual genes. This approach especially targets gene groups whose constituents show subtle but coordinated expression changes, which might not be detected by the usual individual gene analysis. The approach has been quite successful in deriving new information from expression data, and a number of methods and tools have been developed intensively in recent years. We review those methods and currently available tools, classify them according to the statistical methods employed, and discuss their pros and cons. We also discuss several interesting extensions to the methods. 10.1093/bib/bbn001

@article{citeulike:2463876, abstract = {Recently developed gene set analysis methods evaluate differential expression patterns of gene groups instead of those of individual genes. This approach especially targets gene groups whose constituents show subtle but coordinated expression changes, which might not be detected by the usual individual gene analysis. The approach has been quite successful in deriving new information from expression data, and a number of methods and tools have been developed intensively in recent years. We review those methods and currently available tools, classify them according to the statistical methods employed, and discuss their pros and cons. We also discuss several interesting extensions to the methods. 10.1093/bib/bbn001}, author = {Nam, Dougu and Kim, Seon-Young }, citeulike-article-id = {2463876}, doi = {10.1093/bib/bbn001}, journal = {Brief Bioinform}, keywords = {gene-expression, go, review}, month = {January}, pages = {bbn001+}, posted-at = {2008-06-24 03:45:54}, priority = {2}, title = {Gene-set approach for expression pattern analysis}, url = {http://dx.doi.org/10.1093/bib/bbn001}, year = {2008} }

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TY - JOUR ID - citeulike:2463876 L3 - citeulike-article-id:2463876 TI - Gene-set approach for expression pattern analysis JF - Brief Bioinform SP - bbn001 N2 - Recently developed gene set analysis methods evaluate differential expression patterns of gene groups instead of those of individual genes. This approach especially targets gene groups whose constituents show subtle but coordinated expression changes, which might not be detected by the usual individual gene analysis. The approach has been quite successful in deriving new information from expression data, and a number of methods and tools have been developed intensively in recent years. We review those methods and currently available tools, classify them according to the statistical methods employed, and discuss their pros and cons. We also discuss several interesting extensions to the methods. 10.1093/bib/bbn001 KW - gene-expression KW - go KW - review AU - Nam, Dougu AU - Kim, Seon-Young PY - 2008/01/17/ UR - http://dx.doi.org/10.1093/bib/bbn001 ER -

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