Usefulness of apparent diffusion coefficient map in diagnosing prostate carcinoma: Correlation with stepwise histopathology

@article{citeulike:2212171, abstract = {To elucidate the performance of apparent diffusion coefficient (ADC) map in localizing prostate carcinoma (PC) using stepwise histopathology as a reference.Preoperative MR images of 37 patients with PC who had undergone radical prostatectomy were retrospectively evaluated. First, T2-weighted images (T2WI) alone were interpreted (T2WI reading), and then T2WI along with ADC map were interpreted (T2WI/ADC map reading). Sextant-based sensitivity and specificity, and the ratio of the detected volume to the whole tumor volume (\% tumor volume) were compared between the two interpretations, and results were also correlated to Gleason's scores (GS). ADC values were correlated to histological grades.Sensitivity was significantly higher in T2WI/ADC map reading than in T2WI reading (71\% vs. 51\%), but specificity was similar (61\% vs. 60\%). By adding ADC map to T2WI, \% tumor volume detected increased significantly in transitional zone (TZ) lesions, but not in peripheral zone (PZ) lesions. \% tumor volume detected with T2WI/ADC map reading showed a positive correlation with GS of the specimens. Less differentiated PC were associated with lower ADC values and higher detectability.T2WI/ADC map reading was better than T2WI reading in PC detection and localization. This approach may be particularly useful for detecting TZ lesions and biologically aggressive lesions. J. Magn. Reson. Imaging 2007. {\copyright} 2007 Wiley-Liss, Inc.}, address = {Department of Clinical Radiology, Graduate School of Clinical Sciences, Kyushu University, Fukuoka, Japan; Department of Anatomic Pathology, Graduate School of Clinical Sciences, Kyushu University, Fukuoka, Japan; Department of Urology, Graduate School of Clinical Sciences, Kyushu University, Fukuoka, Japan}, author = {Yoshimitsu, Kengo and Kiyoshima, Keijiro and Irie, Hiroyuki and Tajima, Tsuyoshi and Asayama, Yoshiki and Hirakawa, Masakazu and Ishigami, Kousei and Naito, Seiji and Honda, Hiroshi }, citeulike-article-id = {2212171}, doi = {10.1002/jmri.21181}, journal = {Journal of Magnetic Resonance Imaging}, keywords = {apparent-diffusion-coefficient, diagnosis, dw-mri, histology, prostate}, number = {1}, pages = {132--139}, posted-at = {2008-01-09 20:55:48}, priority = {3}, title = {Usefulness of apparent diffusion coefficient map in diagnosing prostate carcinoma: Correlation with stepwise histopathology}, url = {http://dx.doi.org/10.1002/jmri.21181}, volume = {27}, year = {2008} }

TY - JOUR ID - citeulike:2212171 L3 - citeulike-article-id:2212171 TI - Usefulness of apparent diffusion coefficient map in diagnosing prostate carcinoma: Correlation with stepwise histopathology JF - Journal of Magnetic Resonance Imaging VL - 27 IS - 1 SP - 132 EP - 139 AD - Department of Clinical Radiology, Graduate School of Clinical Sciences, Kyushu University, Fukuoka, Japan; Department of Anatomic Pathology, Graduate School of Clinical Sciences, Kyushu University, Fukuoka, Japan; Department of Urology, Graduate School of Clinical Sciences, Kyushu University, Fukuoka, Japan N2 - To elucidate the performance of apparent diffusion coefficient (ADC) map in localizing prostate carcinoma (PC) using stepwise histopathology as a reference.Preoperative MR images of 37 patients with PC who had undergone radical prostatectomy were retrospectively evaluated. First, T2-weighted images (T2WI) alone were interpreted (T2WI reading), and then T2WI along with ADC map were interpreted (T2WI/ADC map reading). Sextant-based sensitivity and specificity, and the ratio of the detected volume to the whole tumor volume (% tumor volume) were compared between the two interpretations, and results were also correlated to Gleason's scores (GS). ADC values were correlated to histological grades.Sensitivity was significantly higher in T2WI/ADC map reading than in T2WI reading (71% vs. 51%), but specificity was similar (61% vs. 60%). By adding ADC map to T2WI, % tumor volume detected increased significantly in transitional zone (TZ) lesions, but not in peripheral zone (PZ) lesions. % tumor volume detected with T2WI/ADC map reading showed a positive correlation with GS of the specimens. Less differentiated PC were associated with lower ADC values and higher detectability.T2WI/ADC map reading was better than T2WI reading in PC detection and localization. This approach may be particularly useful for detecting TZ lesions and biologically aggressive lesions. J. Magn. Reson. Imaging 2007. © 2007 Wiley-Liss, Inc. KW - apparent-diffusion-coefficient KW - diagnosis KW - dw-mri KW - histology KW - prostate AU - Yoshimitsu, Kengo AU - Kiyoshima, Keijiro AU - Irie, Hiroyuki AU - Tajima, Tsuyoshi AU - Asayama, Yoshiki AU - Hirakawa, Masakazu AU - Ishigami, Kousei AU - Naito, Seiji AU - Honda, Hiroshi PY - 2008/// UR - http://dx.doi.org/10.1002/jmri.21181 ER -