Where did the BLOSUM62 alignment score matrix come from?

@article{citeulike:201533, abstract = {Many sequence alignment programs use the BLOSUM62 score matrix to score pairs of aligned residues. Where did BLOSUM62 come from?}, address = {Howard Hughes Medical Institute \& Department of Genetics, Washington University School of Medicine, 4444 Forest Park Blvd., Box 8510, Saint Louis, Missouri 63108, USA. eddy@genetics.wustl.edu}, author = {Eddy, S. R. }, citeulike-article-id = {201533}, comment = {Why is BLOSUM62 called BLOSUM62? Basically, this is because all blocks whose members shared at least 62\% identity with ANY other member of that block were averaged and represented as 1 sequence. }, doi = {http://dx.doi.org/10.1038/nbt0804-1035}, issn = {1087-0156}, journal = {Nat Biotechnol}, keywords = {amino-acid, primer, sequence-alignment, substitution-matrix}, month = {August}, number = {8}, pages = {1035--1036}, posted-at = {2006-10-08 22:31:06}, priority = {5}, title = {Where did the BLOSUM62 alignment score matrix come from?}, url = {http://dx.doi.org/10.1038/nbt0804-1035}, volume = {22}, year = {2004} }

TY - JOUR ID - citeulike:201533 L3 - citeulike-article-id:201533 N2 - Many sequence alignment programs use the BLOSUM62 score matrix to score pairs of aligned residues. Where did BLOSUM62 come from? IS - 8 JF - Nat Biotechnol SN - 1087-0156 AD - Howard Hughes Medical Institute & Department of Genetics, Washington University School of Medicine, 4444 Forest Park Blvd., Box 8510, Saint Louis, Missouri 63108, USA. eddy@genetics.wustl.edu EP - 1036 TI - Where did the BLOSUM62 alignment score matrix come from? VL - 22 SP - 1035 KW - amino-acid KW - primer KW - sequence-alignment KW - substitution-matrix N1 - Why is BLOSUM62 called BLOSUM62? Basically, this is because all blocks whose members shared at least 62% identity with ANY other member of that block were averaged and represented as 1 sequence. AU - Eddy, SR PY - 2004/08// UR - http://dx.doi.org/10.1038/nbt0804-1035 ER -