Comparative analysis of chimpanzee and human Y chromosomes unveils complex evolutionary pathway.

@article{citeulike:455155, abstract = {The mammalian Y chromosome has unique characteristics compared with the autosomes or X chromosomes. Here we report the finished sequence of the chimpanzee Y chromosome (PTRY), including 271 kb of the Y-specific pseudoautosomal region 1 and 12.7 Mb of the male-specific region of the Y chromosome. Greater sequence divergence between the human Y chromosome (HSAY) and PTRY (1.78\%) than between their respective whole genomes (1.23\%) confirmed the accelerated evolutionary rate of the Y chromosome. Each of the 19 PTRY protein-coding genes analyzed had at least one nonsynonymous substitution, and 11 genes had higher nonsynonymous substitution rates than synonymous ones, suggesting relaxation of selective constraint, positive selection or both. We also identified lineage-specific changes, including deletion of a 200-kb fragment from the pericentromeric region of HSAY, expansion of young Alu families in HSAY and accumulation of young L1 elements and long terminal repeat retrotransposons in PTRY. Reconstruction of the common ancestral Y chromosome reflects the dynamic changes in our genomes in the 5-6 million years since speciation.}, address = {RIKEN Genomic Sciences Center, Yokohama 230-0045, Japan.}, author = {Kuroki, Yoko and Toyoda, Atsushi and Noguchi, Hideki and Taylor, Todd D D. and Itoh, Takehiko and Kim, Dae-Soo S. and Kim, Dae-Won W. and Choi, Sang-Haeng H. and Kim, Il-Chul C. and Choi, Han Ho H. and Kim, Yong Sung S. and Satta, Yoko and Saitou, Naruya and Yamada, Tomoyuki and Morishita, Shinichi and Hattori, Masahira and Sakaki, Yoshiyuki and Park, Hong-Seog S. and Fujiyama, Asao }, citeulike-article-id = {455155}, doi = {10.1038/ng1729}, issn = {1061-4036}, journal = {Nat Genet}, keywords = {2008\_gorilla-y}, month = {January}, posted-at = {2007-12-06 21:28:54}, priority = {2}, title = {Comparative analysis of chimpanzee and human Y chromosomes unveils complex evolutionary pathway.}, url = {http://dx.doi.org/10.1038/ng1729}, year = {2006} }

TY - JOUR ID - citeulike:455155 L3 - citeulike-article-id:455155 TI - Comparative analysis of chimpanzee and human Y chromosomes unveils complex evolutionary pathway. JF - Nat Genet AD - RIKEN Genomic Sciences Center, Yokohama 230-0045, Japan. SN - 1061-4036 N2 - The mammalian Y chromosome has unique characteristics compared with the autosomes or X chromosomes. Here we report the finished sequence of the chimpanzee Y chromosome (PTRY), including 271 kb of the Y-specific pseudoautosomal region 1 and 12.7 Mb of the male-specific region of the Y chromosome. Greater sequence divergence between the human Y chromosome (HSAY) and PTRY (1.78%) than between their respective whole genomes (1.23%) confirmed the accelerated evolutionary rate of the Y chromosome. Each of the 19 PTRY protein-coding genes analyzed had at least one nonsynonymous substitution, and 11 genes had higher nonsynonymous substitution rates than synonymous ones, suggesting relaxation of selective constraint, positive selection or both. We also identified lineage-specific changes, including deletion of a 200-kb fragment from the pericentromeric region of HSAY, expansion of young Alu families in HSAY and accumulation of young L1 elements and long terminal repeat retrotransposons in PTRY. Reconstruction of the common ancestral Y chromosome reflects the dynamic changes in our genomes in the 5-6 million years since speciation. KW - 2008_gorilla-y AU - Kuroki, Yoko AU - Toyoda, Atsushi AU - Noguchi, Hideki AU - Taylor, Todd D AU - Itoh, Takehiko AU - Kim, Dae-Soo AU - Kim, Dae-Won AU - Choi, Sang-Haeng AU - Kim, Il-Chul AU - Choi, Han Ho AU - Kim, Yong Sung AU - Satta, Yoko AU - Saitou, Naruya AU - Yamada, Tomoyuki AU - Morishita, Shinichi AU - Hattori, Masahira AU - Sakaki, Yoshiyuki AU - Park, Hong-Seog AU - Fujiyama, Asao PY - 2006/01/01/ UR - http://dx.doi.org/10.1038/ng1729 ER -