Refined genome-wide comparative map of the domestic horse, donkey and human based on cross-species chromosome painting: insight into the occasional fertility of mules.

@article{citeulike:2790583, abstract = {We have made a complete set of painting probes for the domestic horse by degenerate oligonucleotide-primed PCR amplification of flow-sorted horse chromosomes. The horse probes, together with a full set of those available for human, were hybridized onto metaphase chromosomes of human, horse and mule. Based on the hybridization results, we have generated genome-wide comparative chromosome maps involving the domestic horse, donkey and human. These maps define the overall distribution and boundaries of evolutionarily conserved chromosomal segments in the three genomes. Our results shed further light on the karyotypic relationships among these species and, in particular, the chromosomal rearrangements that underlie hybrid sterility and the occasional fertility of mules.}, address = {Centre for Veterinary Science, University of Cambridge, Cambridge CB3 0ES, UK. fy@mole.bio.cam.ac.uk}, author = {Yang, F. and Fu, B. and O'Brien, P. C. and Nie, W. and Ryder, O. A. and Ferguson-Smith, M. A. }, citeulike-article-id = {2790583}, issn = {0967-3849}, journal = {Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology}, keywords = {przewalskii}, number = {1}, pages = {65--76}, posted-at = {2008-05-12 20:20:09}, priority = {2}, title = {Refined genome-wide comparative map of the domestic horse, donkey and human based on cross-species chromosome painting: insight into the occasional fertility of mules.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/14984103}, volume = {12}, year = {2004} }

TY - JOUR ID - citeulike:2790583 L3 - citeulike-article-id:2790583 TI - Refined genome-wide comparative map of the domestic horse, donkey and human based on cross-species chromosome painting: insight into the occasional fertility of mules. JF - Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology VL - 12 IS - 1 SP - 65 EP - 76 AD - Centre for Veterinary Science, University of Cambridge, Cambridge CB3 0ES, UK. fy@mole.bio.cam.ac.uk SN - 0967-3849 N2 - We have made a complete set of painting probes for the domestic horse by degenerate oligonucleotide-primed PCR amplification of flow-sorted horse chromosomes. The horse probes, together with a full set of those available for human, were hybridized onto metaphase chromosomes of human, horse and mule. Based on the hybridization results, we have generated genome-wide comparative chromosome maps involving the domestic horse, donkey and human. These maps define the overall distribution and boundaries of evolutionarily conserved chromosomal segments in the three genomes. Our results shed further light on the karyotypic relationships among these species and, in particular, the chromosomal rearrangements that underlie hybrid sterility and the occasional fertility of mules. KW - przewalskii AU - Yang, F AU - Fu, B AU - O'Brien, PC AU - Nie, W AU - Ryder, OA AU - Ferguson-Smith, MA PY - 2004/// UR - http://view.ncbi.nlm.nih.gov/pubmed/14984103 ER -