SHEF: a vHTS geometrical filter using coefficients of spherical harmonic molecular surfaces.

@article{citeulike:2767067, abstract = {SHEF (spherical harmonic coefficient filter), a geometrical matching procedure constituting a preliminary step in the virtual high throughput screening of large databases of small drug-like molecules, is demonstrated. This filter uses a description of both the binding site of the target and the ligand surfaces using spherical harmonic polynomial expansions. Using this representation, which is based on limited sets of spherical harmonic coefficients, considerably reduces the complexity of surface complementarity calculation. As a first test, 188 known protein-ligand complexes were used, and the results of docking the abstracted ligands into the bare proteins using SHEF were compared to the original X-ray structures. The ability of SHEF to retrieve known ligands "hidden" in a virtual library of 1,000 randomly selected drug-like compounds is also demonstrated.}, address = {Department of Chemistry, Nankai University, Tianjin 300071, People's Republic of China. wscai@nankai.edu.cn}, author = {Cai, W. and Xu, J. and Shao, X. and Leroux, V. and Beautrait, A. and Maigret, B. }, citeulike-article-id = {2767067}, doi = {10.1007/s00894-008-0286-z}, issn = {0948-5023}, journal = {Journal of molecular modeling}, keywords = {harmonics}, month = {May}, number = {5}, pages = {393--401}, posted-at = {2008-05-07 18:37:45}, priority = {2}, title = {SHEF: a vHTS geometrical filter using coefficients of spherical harmonic molecular surfaces.}, url = {http://dx.doi.org/10.1007/s00894-008-0286-z}, volume = {14}, year = {2008} }

TY - JOUR ID - citeulike:2767067 L3 - citeulike-article-id:2767067 TI - SHEF: a vHTS geometrical filter using coefficients of spherical harmonic molecular surfaces. JF - Journal of molecular modeling VL - 14 IS - 5 SP - 393 EP - 401 AD - Department of Chemistry, Nankai University, Tianjin 300071, People's Republic of China. wscai@nankai.edu.cn SN - 0948-5023 N2 - SHEF (spherical harmonic coefficient filter), a geometrical matching procedure constituting a preliminary step in the virtual high throughput screening of large databases of small drug-like molecules, is demonstrated. This filter uses a description of both the binding site of the target and the ligand surfaces using spherical harmonic polynomial expansions. Using this representation, which is based on limited sets of spherical harmonic coefficients, considerably reduces the complexity of surface complementarity calculation. As a first test, 188 known protein-ligand complexes were used, and the results of docking the abstracted ligands into the bare proteins using SHEF were compared to the original X-ray structures. The ability of SHEF to retrieve known ligands "hidden" in a virtual library of 1,000 randomly selected drug-like compounds is also demonstrated. KW - harmonics AU - Cai, W AU - Xu, J AU - Shao, X AU - Leroux, V AU - Beautrait, A AU - Maigret, B PY - 2008/05// UR - http://dx.doi.org/10.1007/s00894-008-0286-z ER -