A Gene-Coexpression Network for Global Discovery of Conserved Genetic Modules

by: Joshua M Stuart, Eran Segal, Daphne Koller, Stuart K Kim

Science, Vol. 302, No. 5643. (10 October 2003), pp. 249-255.

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this article has also compared different methods used to measure the correlation between gene vectors.

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Abstract

To elucidate gene function on a global scale, we identified pairs of genes that are coexpressed over 3182 DNA microarrays from humans, flies, worms, and yeast. We found 22,163 such coexpression relationships, each of which has been conserved across evolution. This conservation implies that the coexpression of these gene pairs confers a selective advantage and therefore that these genes are functionally related. Manyof these relationships provide strong evidence for the involvement of new genes in core biological functions such as the cell cycle, secretion, and protein expression. We experimentallyconfirmed the predictions implied bysome of these links and identified cell proliferation functions for several genes. By assembling these links into a gene-coexpression network, we found several components that were animal-specific as well as interrelationships between newly evolved and ancient modules.

@article{citeulike:331864, abstract = {To elucidate gene function on a global scale, we identified pairs of genes that are coexpressed over 3182 DNA microarrays from humans, flies, worms, and yeast. We found 22,163 such coexpression relationships, each of which has been conserved across evolution. This conservation implies that the coexpression of these gene pairs confers a selective advantage and therefore that these genes are functionally related. Manyof these relationships provide strong evidence for the involvement of new genes in core biological functions such as the cell cycle, secretion, and protein expression. We experimentallyconfirmed the predictions implied bysome of these links and identified cell proliferation functions for several genes. By assembling these links into a gene-coexpression network, we found several components that were animal-specific as well as interrelationships between newly evolved and ancient modules.}, author = {Stuart, Joshua M. and Segal, Eran and Koller, Daphne and Kim, Stuart K. }, citeulike-article-id = {331864}, doi = {http://dx.doi.org/10.1126/science.1087447}, journal = {Science}, keywords = {modules, network}, month = {October}, number = {5643}, pages = {249--255}, posted-at = {2007-02-24 15:13:01}, priority = {0}, title = {A Gene-Coexpression Network for Global Discovery of Conserved Genetic Modules}, url = {http://dx.doi.org/10.1126/science.1087447}, volume = {302}, year = {2003} }

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TY - JOUR ID - citeulike:331864 L3 - citeulike-article-id:331864 TI - A Gene-Coexpression Network for Global Discovery of Conserved Genetic Modules JF - Science VL - 302 IS - 5643 SP - 249 EP - 255 N2 - To elucidate gene function on a global scale, we identified pairs of genes that are coexpressed over 3182 DNA microarrays from humans, flies, worms, and yeast. We found 22,163 such coexpression relationships, each of which has been conserved across evolution. This conservation implies that the coexpression of these gene pairs confers a selective advantage and therefore that these genes are functionally related. Manyof these relationships provide strong evidence for the involvement of new genes in core biological functions such as the cell cycle, secretion, and protein expression. We experimentallyconfirmed the predictions implied bysome of these links and identified cell proliferation functions for several genes. By assembling these links into a gene-coexpression network, we found several components that were animal-specific as well as interrelationships between newly evolved and ancient modules. KW - modules KW - network AU - Stuart, Joshua AU - Segal, Eran AU - Koller, Daphne AU - Kim, Stuart PY - 2003/10/10/ UR - http://dx.doi.org/10.1126/science.1087447 ER -

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