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superpyrins herg [27 articles]

Neue Publikationen in superpyrins Bibliothek eingetragen unter dem Bezeichner: herg. You can also see everyone's herg.
  • Overcoming Undesirable hERG Potency of Chemokine Receptor Antagonists Using Baseline Lipophilicity Relationships
    J. Med. Chem., Vol. 51, No. 5. (13 March 2008), pp. 1162-1178.
    by Igor Shamovsky, Stephen Connolly, Laurent David, Svetlana Ivanova, Bo Nordén, Brian Springthorpe, Klaus Urbahns
    posted to herg lipophilicity by superpyrin on 2008-05-22 08:37:19 as **
  • Dofetilide block involves interactions with open and inactivated states of HERG channels.
    Pflugers Arch, Vol. 443, No. 4. (February 2002), pp. 520-531.
    by M Weerapura, TE Hébert, S Nattel
    posted to herg by superpyrin on 2008-04-06 07:31:42 as ** along with 1 person tomb
  • Structural determinants of HERG channel block by clofilium and ibutilide.
    Molecular pharmacology, Vol. 66, No. 2. (August 2004), pp. 240-249.
    by M Perry, MJ de Groot, R Helliwell, D Leishman, M Tristani-Firouzi, MC Sanguinetti, J Mitcheson
    posted to herg by superpyrin on 2008-04-02 14:43:57 as **
  • High-throughput electrophysiology: an emerging paradigm for ion-channel screening and physiology
    Nature Reviews Drug Discovery, Vol. 7, No. 4., pp. 358-368.
    by John Dunlop, Mark Bowlby, Ravikumar Peri, Dmytro Vasilyev, Robert Arias
    posted to herg ion-channel screening by superpyrin on 2008-04-02 08:31:41 as ***
  • HERG binding specificity and binding site structure: evidence from a fragment-based evolutionary computing SAR study
    Progress in Biophysics and Molecular Biology, Vol. 86, No. 2. (October 2004), pp. 205-233.
    by William Bains, Antranig Basman, Cat White
    posted to herg by superpyrin on 2008-04-01 16:45:45 as **
  • Predictive in silico modeling for hERG channel blockers
    Drug Discovery Today, Vol. 10, No. 2. (15 January 2005), pp. 149-155.
    by Alex M Aronov
    posted to herg by superpyrin on 2008-04-01 16:33:36 as **
  • Three-Dimensional Quantitative Structure-Activity Relationship for Inhibition of Human Ether-a-Go-Go-Related Gene Potassium Channel
    J Pharmacol Exp Ther, Vol. 301, No. 2. (1 May 2002), pp. 427-434.
    by Sean Ekins, William J Crumb, Dustan R Sarazan, James H Wikel, Steven A Wrighton
    posted to herg by superpyrin on 2008-04-01 16:31:02 as **
  • QT prolongation through hERG K(+) channel blockade: current knowledge and strategies for the early prediction during drug development.
    Med Res Rev, Vol. 25, No. 2. (March 2005), pp. 133-166.
    by M Recanatini, E Poluzzi, M Masetti, A Cavalli, F De Ponti
    posted to herg by superpyrin on 2007-07-01 11:19:17 as **
  • hERG potassium channels and cardiac arrhythmia
    Nature, Vol. 440, No. 7083. (22 March 2006), pp. 463-469.
    by Michael C Sanguinetti, Martin Tristani-Firouzi
    posted to herg by superpyrin on 2007-07-01 09:17:57 as read along with 1 person tomb
  • A Family of Potassium Channel Genes Related to eag in Drosophila and Mammals
    PNAS, Vol. 91, No. 8. (12 April 1994), pp. 3438-3442.
    by Jw Warmke, B Ganetzky
    posted to herg by superpyrin on 2007-07-01 08:52:12 as **
  • A two-state homology model of the hERG K+ channel: application to ligand binding.
    Bioorg Med Chem Lett, Vol. 15, No. 6. (15 March 2005), pp. 1737-1741.
    by R Rajamani, BA Tounge, J Li, CH Reynolds
    posted to herg by superpyrin on 2007-06-04 14:40:22 as **
  • Exploring blocker binding to a homology model of the open hERG K+ channel using docking and molecular dynamics methods.
    FEBS Lett, Vol. 579, No. 13. (23 May 2005), pp. 2939-2944.
    by F Osterberg, J Aqvist
    posted to herg by superpyrin on 2007-06-04 14:38:46 as **
  • A novel structure-based virtual screening model for the hERG channel blockers.
    Biochem Biophys Res Commun, Vol. 355, No. 4. (20 April 2007), pp. 889-894.
    by L Du, M Li, Q You, L Xia
    posted to herg by superpyrin on 2007-06-04 14:38:07 as **
  • A novel hypothesis for the binding mode of HERG channel blockers.
    Biochem Biophys Res Commun, Vol. 344, No. 1. (26 May 2006), pp. 72-78.
    by H Choe, KH Nah, SN Lee, HS Lee, HS Lee, SH Jo, CH Leem, YJ Jang
    posted to herg by superpyrin on 2007-06-04 14:19:08 as **
  • Determination of hERG channel blockers using a decision tree.
    Bioorg Med Chem, Vol. 14, No. 15. (1 August 2006), pp. 5325-5332.
    by MM Gepp, MC Hutter
    posted to herg by superpyrin on 2007-06-04 14:17:26 as **
  • A QSAR model of HERG binding using a large, diverse, and internally consistent training set.
    Chem Biol Drug Des, Vol. 67, No. 4. (April 2006), pp. 284-296.
    by M Seierstad, DK Agrafiotis
    posted to herg by superpyrin on 2007-06-04 14:14:10 as **
  • An Accurate and Interpretable Bayesian Classification Model for Prediction of hERG Liability
    ChemMedChem, Vol. 1, No. 3. (2006), pp. 315-322.
    by Hongmao Sun
    posted to herg by superpyrin on 2007-06-04 14:06:13 as **
  • In Silico Classification of hERG Channel Blockers: a Knowledge-Based Strategy
    ChemMedChem, Vol. 1, No. 6. (2006), pp. 622-630.
    by Elodie Dubus, Ismaïl Ijjaali, François Petitet, André Michel
    posted to herg by superpyrin on 2007-06-04 14:01:43 as **
  • Common pharmacophores for uncharged human ether-a-go-go-related gene (hERG) blockers.
    J Med Chem, Vol. 49, No. 23. (16 November 2006), pp. 6917-6921.
    by AM Aronov
    posted to herg by superpyrin on 2007-06-04 13:54:43 as **
  • HERG is protected from pharmacological block by alpha-1,2-glucosyltransferase function.
    J Biol Chem, Vol. 282, No. 8. (23 February 2007), pp. 5506-5513.
    by T Nakajima, K Hayashi, PC Viswanathan, MY Kim, M Anghelescu, KA Barksdale, W Shuai, JR Balser, S Kupershmidt
    posted to herg by superpyrin on 2007-06-04 13:54:23 as **
  • A quantitative assessment of hERG liability as a function of lipophilicity
    Bioorganic & Medicinal Chemistry Letters, Vol. 17, No. 6. (15 March 2007), pp. 1759-1764.
    by Michael J Waring, Craig Johnstone
    posted to herg lipophilicity by superpyrin on 2007-06-04 13:42:22 as ** along with 1 person daevans
  • Molecular dynamics and continuum electrostatics studies of inactivation in the HERG potassium channel.
    J Phys Chem B, Vol. 111, No. 5. (8 February 2007), pp. 1090-1098.
    by R Kutteh, JI Vandenberg, S Kuyucak
    posted to herg by superpyrin on 2007-06-04 13:32:15 as **
  • The hERG potassium channel as a therapeutic target
    Expert Opinion on Therapeutic Targets, Vol. 11 (2007), pp. 321-336.
    by Harry J Witchel‌
    posted to herg by superpyrin on 2007-06-04 13:30:03 as ***
  • Drug block of the hERG potassium channel: Insight from modeling.
    Proteins, Vol. 68, No. 2. (19 April 2007), pp. 568-580.
    by Phillip J J Stansfeld, Peter Gedeck, Martin Gosling, Brian Cox, John S S Mitcheson, Michael J J Sutcliffe
    posted to herg by superpyrin on 2007-06-04 13:09:16 as *** along with 1 person dimka
  • Modulation of HERG Gating by a Charge Cluster in the N-Terminal Proximal Domain
    Biophys. J., Vol. 91, No. 12. (15 December 2006), pp. 4381-4391.
    by JB Saenen, AJ Labro, A Raes, DJ Snyders
    posted to herg by superpyrin on 2007-06-04 12:57:57 as **
  • Drug Binding Interactions in the Inner Cavity of hERG Channels: Molecular Insights from Structure-Activity Relationships of Clofilium and Ibutilide Analogs
    Mol Pharmacol, Vol. 69, No. 2. (1 February 2006), pp. 509-519.
    by Matthew Perry, Phillip J Stansfeld, Joanne Leaney, Claire Wood, Marcel J de Groot, Derek Leishman, Michael J Sutcliffe, John S Mitcheson
    posted to herg by superpyrin on 2007-06-04 12:55:38 as **
  • Molecular Determinants of hERG Channel Block
    Mol Pharmacol, Vol. 69, No. 5. (1 May 2006), pp. 1709-1716.
    by Kaichiro Kamiya, Ryoko Niwa, John S Mitcheson, Michael C Sanguinetti
    posted to herg by superpyrin on 2007-06-04 12:48:30 as **
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