P. aeruginosa quorum-sensing systems and virulence

by: Roger S Smith, Barbara H Iglewski

Current Opinion in Microbiology, Vol. 6, No. 1. (February 2003), pp. 56-60.

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Abstract

Quorum sensing is an important mechanism for the regulation of genes in many Gram-negative and Gram-positive bacteria. In the opportunistic pathogen Pseudomonas aeruginosa, the absence of one or more components of the quorum-sensing system results in a significant reduction in virulence. Recent advances in the past year have demonstrated that the quorum-sensing signal molecule 3O-C12-HSL is also a potent stimulator of multiple eukaryotic cells and thus may alter the host response during P. aeruginosa infections. Therefore, via the regulation of multiple factors and the production of 3O-C12-HSL, quorum-sensing systems have a significant effect on the virulence of the bacteria and also on how the host responds to P. aeruginosa infections.

@article{citeulike:2844572, abstract = {Quorum sensing is an important mechanism for the regulation of genes in many Gram-negative and Gram-positive bacteria. In the opportunistic pathogen Pseudomonas aeruginosa, the absence of one or more components of the quorum-sensing system results in a significant reduction in virulence. Recent advances in the past year have demonstrated that the quorum-sensing signal molecule 3O-C12-HSL is also a potent stimulator of multiple eukaryotic cells and thus may alter the host response during P. aeruginosa infections. Therefore, via the regulation of multiple factors and the production of 3O-C12-HSL, quorum-sensing systems have a significant effect on the virulence of the bacteria and also on how the host responds to P. aeruginosa infections.}, author = {Smith, Roger S. and Iglewski, Barbara H. }, citeulike-article-id = {2844572}, doi = {http://dx.doi.org/10.1016/S1369-5274(03)00008-0}, journal = {Current Opinion in Microbiology}, keywords = {cystic-fibrosis, quorum-sensing}, month = {February}, number = {1}, pages = {56--60}, posted-at = {2008-05-29 15:31:24}, priority = {2}, title = {P. aeruginosa quorum-sensing systems and virulence}, url = {http://dx.doi.org/10.1016/S1369-5274(03)00008-0}, volume = {6}, year = {2003} }

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TY - JOUR ID - citeulike:2844572 L3 - citeulike-article-id:2844572 N2 - Quorum sensing is an important mechanism for the regulation of genes in many Gram-negative and Gram-positive bacteria. In the opportunistic pathogen Pseudomonas aeruginosa, the absence of one or more components of the quorum-sensing system results in a significant reduction in virulence. Recent advances in the past year have demonstrated that the quorum-sensing signal molecule 3O-C12-HSL is also a potent stimulator of multiple eukaryotic cells and thus may alter the host response during P. aeruginosa infections. Therefore, via the regulation of multiple factors and the production of 3O-C12-HSL, quorum-sensing systems have a significant effect on the virulence of the bacteria and also on how the host responds to P. aeruginosa infections. IS - 1 JF - Current Opinion in Microbiology EP - 60 TI - P. aeruginosa quorum-sensing systems and virulence VL - 6 SP - 56 KW - cystic-fibrosis KW - quorum-sensing AU - Smith, Roger AU - Iglewski, Barbara PY - 2003/02// UR - http://dx.doi.org/10.1016/S1369-5274(03)00008-0 ER -

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