Bacterial quorum sensing: a new target for anti-infective immunotherapy.

@article{citeulike:2837700, abstract = {BACKGROUND: Cell-to-cell communication via exchange of small molecules, 'autoinducers', is a widespread phenomenon among Gram-negative and -positive bacteria. This intercellular signaling that synchronizes population-wide gene expression in a cell-density-dependent manner is termed 'quorum sensing' (QS). The discovery that Gram-negative bacteria employ non-peptide structures, N-acyl homoserine lactones, to globally regulate production of secondary metabolites and proteins, initiated a new area of research. Subsequently, other quorum-sensing systems and small signaling molecules were identified. With the emergence of antibiotic-resistant bacteria, most prominently methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa, new approaches for combating infections are needed. Inhibition of QS results in attenuation of virulence rather than direct killing of microbes. OBJECTIVE: We highlight current trends in preventing bacterial infections using quorum-quenching strategies. METHODS: We mainly focus on P. aeruginosa and S. aureus and their QS systems as targets for intervention. RESULTS/CONCLUSION: New research strongly suggests that QS systems represent attractive targets for discovery of novel anti-infective agents, including immunotherapeutic strategies.}, address = {Skaggs Institute for Chemical Biology, Department of Chemistry and Immunology, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.}, author = {Kaufmann, G. F. and Park, J. and Janda, K. D. }, citeulike-article-id = {2837700}, doi = {http://dx.doi.org/10.1517/14712598.8.6.719}, issn = {1744-7682}, journal = {Expert opinion on biological therapy}, keywords = {quorum-sensing}, month = {June}, number = {6}, pages = {719--724}, posted-at = {2008-05-27 15:47:10}, priority = {2}, title = {Bacterial quorum sensing: a new target for anti-infective immunotherapy.}, url = {http://dx.doi.org/10.1517/14712598.8.6.719}, volume = {8}, year = {2008} }

TY - JOUR ID - citeulike:2837700 L3 - citeulike-article-id:2837700 N2 - BACKGROUND: Cell-to-cell communication via exchange of small molecules, 'autoinducers', is a widespread phenomenon among Gram-negative and -positive bacteria. This intercellular signaling that synchronizes population-wide gene expression in a cell-density-dependent manner is termed 'quorum sensing' (QS). The discovery that Gram-negative bacteria employ non-peptide structures, N-acyl homoserine lactones, to globally regulate production of secondary metabolites and proteins, initiated a new area of research. Subsequently, other quorum-sensing systems and small signaling molecules were identified. With the emergence of antibiotic-resistant bacteria, most prominently methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa, new approaches for combating infections are needed. Inhibition of QS results in attenuation of virulence rather than direct killing of microbes. OBJECTIVE: We highlight current trends in preventing bacterial infections using quorum-quenching strategies. METHODS: We mainly focus on P. aeruginosa and S. aureus and their QS systems as targets for intervention. RESULTS/CONCLUSION: New research strongly suggests that QS systems represent attractive targets for discovery of novel anti-infective agents, including immunotherapeutic strategies. IS - 6 JF - Expert opinion on biological therapy SN - 1744-7682 AD - Skaggs Institute for Chemical Biology, Department of Chemistry and Immunology, 10550 North Torrey Pines Road, La Jolla, California 92037, USA. EP - 724 TI - Bacterial quorum sensing: a new target for anti-infective immunotherapy. VL - 8 SP - 719 KW - quorum-sensing AU - Kaufmann, GF AU - Park, J AU - Janda, KD PY - 2008/06// UR - http://dx.doi.org/10.1517/14712598.8.6.719 ER -