The effect of cytochrome P450 metabolism on drug response, interactions, and adverse effects.

@article{citeulike:1590952, abstract = {Cytochrome P450 enzymes are essential for the metabolism of many medications. Although this class has more than 50 enzymes, six of them metabolize 90 percent of drugs, with the two most significant enzymes being CYP3A4 and CYP2D6. Genetic variability (polymorphism) in these enzymes may influence a patient's response to commonly prescribed drug classes, including beta blockers and antidepressants. Cytochrome P450 enzymes can be inhibited or induced by drugs, resulting in clinically significant drug-drug interactions that can cause unanticipated adverse reactions or therapeutic failures. Interactions with warfarin, antidepressants, antiepileptic drugs, and statins often involve the cytochrome P450 enzymes. Knowledge of the most important drugs metabolized by cytochrome P450 enzymes, as well as the most potent inhibiting and inducing drugs, can help minimize the possibility of adverse drug reactions and interactions. Although genotype tests can determine if a patient has a specific enzyme polymorphism, it has not been determined if routine use of these tests will improve outcomes.}, address = {Department of Family and Community Medicine, Eastern Virginia Medical School, Norfolk, Virginia 23507, USA.}, author = {Lynch, T. and Price, A. }, citeulike-article-id = {1590952}, issn = {0002-838X}, journal = {Am Fam Physician}, keywords = {2d6, 3a4, p450}, month = {August}, number = {3}, pages = {391--396}, posted-at = {2007-10-14 09:57:38}, priority = {2}, title = {The effect of cytochrome P450 metabolism on drug response, interactions, and adverse effects.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/17708140}, volume = {76}, year = {2007} }

TY - JOUR ID - citeulike:1590952 L3 - citeulike-article-id:1590952 N2 - Cytochrome P450 enzymes are essential for the metabolism of many medications. Although this class has more than 50 enzymes, six of them metabolize 90 percent of drugs, with the two most significant enzymes being CYP3A4 and CYP2D6. Genetic variability (polymorphism) in these enzymes may influence a patient's response to commonly prescribed drug classes, including beta blockers and antidepressants. Cytochrome P450 enzymes can be inhibited or induced by drugs, resulting in clinically significant drug-drug interactions that can cause unanticipated adverse reactions or therapeutic failures. Interactions with warfarin, antidepressants, antiepileptic drugs, and statins often involve the cytochrome P450 enzymes. Knowledge of the most important drugs metabolized by cytochrome P450 enzymes, as well as the most potent inhibiting and inducing drugs, can help minimize the possibility of adverse drug reactions and interactions. Although genotype tests can determine if a patient has a specific enzyme polymorphism, it has not been determined if routine use of these tests will improve outcomes. IS - 3 JF - Am Fam Physician SN - 0002-838X AD - Department of Family and Community Medicine, Eastern Virginia Medical School, Norfolk, Virginia 23507, USA. EP - 396 TI - The effect of cytochrome P450 metabolism on drug response, interactions, and adverse effects. VL - 76 SP - 391 KW - 2d6 KW - 3a4 KW - p450 AU - Lynch, T AU - Price, A PY - 2007/08/01/ UR - http://view.ncbi.nlm.nih.gov/pubmed/17708140 ER -