Nanoparticle Self-Assembly Gated by Logical Proteolytic Triggers

@article{citeulike:2649986, abstract = {Abstract: The emergent electromagnetic properties of nanoparticle self-assemblies are being harnessed to build new medical and biochemical assays with unprecedented sensitivity. While current self-assembly assays have displayed superior sensitivity for single molecular targets, the development of systems with the capacity to process multiple inputs may more effectively decipher complex disease signatures such as cancer. Herein, we present the design and synthesis of nanoparticles that perform Boolean logic operations using two proteolytic inputs associated with unique aspects of tumorigenesis (MMP2 and MMP7). Using dynamic light scatting, fluorescence, and MRI, we show that logical AND and OR functions can control the self-assembly of disperse superparamagnetic nanoparticles and enable remote, NMR detection of nanoparticle computation. In the future, by increasing the complexity of assembly triggers, nanoparticles may be tailored to sense a diversity of disease inputs in vitro and potentially in vivo.}, address = {Harvard-MIT Division of Health Sciences and Technology, Cambridge, Massachusetts, Department of Chemistry and Biochemistry, University of California, San Diego, California, MIT Electrical Engineering and Computer Science, Cambridge, Massachusetts, and Brigham \& Women's Hospital, Boston, Massachusetts}, author = {Vonmaltzahn, G. and Harris, T. J. and Park, J. H. and Min, D. H. and Schmidt, A. J. and Sailor, M. J. and Bhatia, S. N. }, citeulike-article-id = {2649986}, doi = {10.1021/ja070461l}, journal = {J. Am. Chem. Soc.}, keywords = {cancer, ccne, nanotech}, month = {May}, number = {19}, pages = {6064--6065}, posted-at = {2008-05-15 11:47:27}, priority = {0}, title = {Nanoparticle Self-Assembly Gated by Logical Proteolytic Triggers}, url = {http://dx.doi.org/10.1021/ja070461l}, volume = {129}, year = {2007} }

TY - JOUR ID - citeulike:2649986 L3 - citeulike-article-id:2649986 TI - Nanoparticle Self-Assembly Gated by Logical Proteolytic Triggers JF - J. Am. Chem. Soc. VL - 129 IS - 19 SP - 6064 EP - 6065 AD - Harvard-MIT Division of Health Sciences and Technology, Cambridge, Massachusetts, Department of Chemistry and Biochemistry, University of California, San Diego, California, MIT Electrical Engineering and Computer Science, Cambridge, Massachusetts, and Brigham & Women's Hospital, Boston, Massachusetts N2 - Abstract: The emergent electromagnetic properties of nanoparticle self-assemblies are being harnessed to build new medical and biochemical assays with unprecedented sensitivity. While current self-assembly assays have displayed superior sensitivity for single molecular targets, the development of systems with the capacity to process multiple inputs may more effectively decipher complex disease signatures such as cancer. Herein, we present the design and synthesis of nanoparticles that perform Boolean logic operations using two proteolytic inputs associated with unique aspects of tumorigenesis (MMP2 and MMP7). Using dynamic light scatting, fluorescence, and MRI, we show that logical AND and OR functions can control the self-assembly of disperse superparamagnetic nanoparticles and enable remote, NMR detection of nanoparticle computation. In the future, by increasing the complexity of assembly triggers, nanoparticles may be tailored to sense a diversity of disease inputs in vitro and potentially in vivo. KW - cancer KW - ccne KW - nanotech AU - Vonmaltzahn, G AU - Harris, TJ AU - Park, JH AU - Min, DH AU - Schmidt, AJ AU - Sailor, MJ AU - Bhatia, SN PY - 2007/05/16/ UR - http://dx.doi.org/10.1021/ja070461l ER -