Silver Nanoparticle-Oligonucleotide Conjugates Based on DNA with Triple Cyclic Disulfide Moieties

@article{citeulike:2616456, abstract = {Abstract: We report a new strategy for preparing silver nanoparticle-oligonucleotide conjugates that are based upon DNA with cyclic disulfide-anchoring groups. These particles are extremely stable and can withstand NaCl concentrations up to 1.0 M. When silver nanoparticles functionalized with complementary sequences are combined, they assemble to form DNA-linked nanoparticle networks. This assembly process is reversible with heating and is associated with a red shifting of the particle surface plasmon resonance and a concomitant color change from yellow to pale red. Analogous to the oligonucleotide-functionalized gold nanoparticles, these particles also exhibit highly cooperative binding properties with extremely sharp melting transitions. This work is an important step toward using silver nanoparticle-oligonucleotide conjugates for a variety of purposes, including molecular diagnostic labels, synthons in programmable materials synthesis approaches, and functional components for nanoelectronic and plasmonic devices.}, address = {Department of Chemistry and International Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208}, author = {Lee, J. S. and Lytton-Jean, A. K. R. and Hurst, S. J. and Mirkin, C. A. }, citeulike-article-id = {2616456}, doi = {http://dx.doi.org/10.1021/nl071108g}, journal = {Nano Lett.}, keywords = {ccne, imaging, nanotech}, month = {July}, number = {7}, pages = {2112--2115}, posted-at = {2008-05-07 11:16:30}, priority = {0}, title = {Silver Nanoparticle-Oligonucleotide Conjugates Based on DNA with Triple Cyclic Disulfide Moieties}, url = {http://dx.doi.org/10.1021/nl071108g}, volume = {7}, year = {2007} }

TY - JOUR ID - citeulike:2616456 L3 - citeulike-article-id:2616456 TI - Silver Nanoparticle-Oligonucleotide Conjugates Based on DNA with Triple Cyclic Disulfide Moieties JF - Nano Lett. VL - 7 IS - 7 SP - 2112 EP - 2115 AD - Department of Chemistry and International Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208 N2 - Abstract: We report a new strategy for preparing silver nanoparticle-oligonucleotide conjugates that are based upon DNA with cyclic disulfide-anchoring groups. These particles are extremely stable and can withstand NaCl concentrations up to 1.0 M. When silver nanoparticles functionalized with complementary sequences are combined, they assemble to form DNA-linked nanoparticle networks. This assembly process is reversible with heating and is associated with a red shifting of the particle surface plasmon resonance and a concomitant color change from yellow to pale red. Analogous to the oligonucleotide-functionalized gold nanoparticles, these particles also exhibit highly cooperative binding properties with extremely sharp melting transitions. This work is an important step toward using silver nanoparticle-oligonucleotide conjugates for a variety of purposes, including molecular diagnostic labels, synthons in programmable materials synthesis approaches, and functional components for nanoelectronic and plasmonic devices. KW - ccne KW - imaging KW - nanotech AU - Lee, JS AU - Lytton-Jean, AKR AU - Hurst, SJ AU - Mirkin, CA PY - 2007/07/11/ UR - http://dx.doi.org/10.1021/nl071108g ER -