The sea urchin kinome: a first look.

@article{citeulike:2906069, abstract = {This paper reports a preliminary in silico analysis of the sea urchin kinome. The predicted protein kinases in the sea urchin genome were identified, annotated and classified, according to both function and kinase domain taxonomy. The results show that the sea urchin kinome, consisting of 353 protein kinases, is closer to the Drosophila kinome (239) than the human kinome (518) with respect to total kinase number. However, the diversity of sea urchin kinases is surprisingly similar to humans, since the urchin kinome is missing only 4 of 186 human subfamilies, while Drosophila lacks 24. Thus, the sea urchin kinome combines the simplicity of a non-duplicated genome with the diversity of function and signaling previously considered to be vertebrate-specific. More than half of the sea urchin kinases are involved with signal transduction, and approximately 88\% of the signaling kinases are expressed in the developing embryo. These results support the strength of this nonchordate deuterostome as a pivotal developmental and evolutionary model organism.}, address = {DCMB Group, Duke University, Box 91000, Durham, NC 27708, USA. cabrad@duke.edu}, author = {Bradham, C. A. and Foltz, K. R. and Beane, W. S. and Arnone, M. I. and Rizzo, F. and Coffman, J. A. and Mushegian, A. and Goel, M. and Morales, J. and Geneviere, A. M. and Lapraz, F. and Robertson, A. J. and Kelkar, H. and Loza-Coll, M. and Townley, I. K. and Raisch, M. and Roux, M. M. and Lepage, T. and Gache, C. and McClay, D. R. and Manning, G. }, citeulike-article-id = {2906069}, doi = {http://dx.doi.org/10.1016/j.ydbio.2006.08.074}, issn = {0012-1606}, journal = {Developmental biology}, keywords = {kinome}, month = {December}, number = {1}, pages = {180--193}, posted-at = {2008-06-18 20:30:12}, priority = {2}, title = {The sea urchin kinome: a first look.}, url = {http://dx.doi.org/10.1016/j.ydbio.2006.08.074}, volume = {300}, year = {2006} }

TY - JOUR ID - citeulike:2906069 L3 - citeulike-article-id:2906069 N2 - This paper reports a preliminary in silico analysis of the sea urchin kinome. The predicted protein kinases in the sea urchin genome were identified, annotated and classified, according to both function and kinase domain taxonomy. The results show that the sea urchin kinome, consisting of 353 protein kinases, is closer to the Drosophila kinome (239) than the human kinome (518) with respect to total kinase number. However, the diversity of sea urchin kinases is surprisingly similar to humans, since the urchin kinome is missing only 4 of 186 human subfamilies, while Drosophila lacks 24. Thus, the sea urchin kinome combines the simplicity of a non-duplicated genome with the diversity of function and signaling previously considered to be vertebrate-specific. More than half of the sea urchin kinases are involved with signal transduction, and approximately 88% of the signaling kinases are expressed in the developing embryo. These results support the strength of this nonchordate deuterostome as a pivotal developmental and evolutionary model organism. IS - 1 JF - Developmental biology SN - 0012-1606 AD - DCMB Group, Duke University, Box 91000, Durham, NC 27708, USA. cabrad@duke.edu EP - 193 TI - The sea urchin kinome: a first look. VL - 300 SP - 180 KW - kinome AU - Bradham, CA AU - Foltz, KR AU - Beane, WS AU - Arnone, MI AU - Rizzo, F AU - Coffman, JA AU - Mushegian, A AU - Goel, M AU - Morales, J AU - Geneviere, AM AU - Lapraz, F AU - Robertson, AJ AU - Kelkar, H AU - Loza-Coll, M AU - Townley, IK AU - Raisch, M AU - Roux, MM AU - Lepage, T AU - Gache, C AU - McClay, DR AU - Manning, G PY - 2006/12/01/ UR - http://dx.doi.org/10.1016/j.ydbio.2006.08.074 ER -