Why have serine/threonine/tyrosine kinases been evolutionarily selected in eukaryotic signaling cascades?

@article{citeulike:2734763, abstract = {The signal transduction systems of eukaryotes are different from those of prokaryotes with respect to their structures and mechanisms. The main signal transduction system of prokaryotes called the two-component system (TCS) is a one-step phosphorelay system composed of a histidine kinase (HK) while the central signal transduction system of eukaryotes called the mitogen-activated protein kinase (MAPK) cascade system (MCS) is a multi-step phosphorelay system composed of serine/threonine/tyrosine kinases (STYKs). The two signal transduction systems are also different in their transphosphorylation mechanisms. HK in the TCS transfers its own phosphate group to the response regulator protein while STYKs in the MCS phosphorylate other proteins using ATP. We were intrigued by the different dynamics resulting from such differences and wondered why STYKs instead of HKs have been evolutionarily selected in eukaryotic signaling cascades. In this paper, we compared the dynamical characteristics of two mathematical models which reflect such differences between the TCS and the MCS, and found that STYKs are more appropriate for cascade structures in eukaryotic signal transduction than HK with respect to the duration and settling time of response signals.}, address = {Interdisciplinary Program in Bioinformatics, Seoul National University, Gwanak-gu, Seoul 151-747, Republic of Korea; Department of Bio and Brain Engineering and KI for the BioCentury, Korea Advanced Institute of Science and Technology (KAIST), 335 Gwahangno, Yuseong-gu, Daejeon 305-701, Republic of Korea.}, author = {Choi, Hyung-Seok S. and Kim, Jeong-Rae R. and Lee, Sang-Woo W. and Cho, Kwang-Hyun H. }, citeulike-article-id = {2734763}, doi = {http://dx.doi.org/10.1016/j.compbiolchem.2008.02.005}, issn = {1476-9271}, journal = {Computational biology and chemistry}, keywords = {bioinformatics, evolution, kinase, signaling}, month = {February}, posted-at = {2008-07-03 15:38:52}, priority = {3}, title = {Why have serine/threonine/tyrosine kinases been evolutionarily selected in eukaryotic signaling cascades?}, url = {http://dx.doi.org/10.1016/j.compbiolchem.2008.02.005}, year = {2008} }

TY - JOUR ID - citeulike:2734763 L3 - citeulike-article-id:2734763 N2 - The signal transduction systems of eukaryotes are different from those of prokaryotes with respect to their structures and mechanisms. The main signal transduction system of prokaryotes called the two-component system (TCS) is a one-step phosphorelay system composed of a histidine kinase (HK) while the central signal transduction system of eukaryotes called the mitogen-activated protein kinase (MAPK) cascade system (MCS) is a multi-step phosphorelay system composed of serine/threonine/tyrosine kinases (STYKs). The two signal transduction systems are also different in their transphosphorylation mechanisms. HK in the TCS transfers its own phosphate group to the response regulator protein while STYKs in the MCS phosphorylate other proteins using ATP. We were intrigued by the different dynamics resulting from such differences and wondered why STYKs instead of HKs have been evolutionarily selected in eukaryotic signaling cascades. In this paper, we compared the dynamical characteristics of two mathematical models which reflect such differences between the TCS and the MCS, and found that STYKs are more appropriate for cascade structures in eukaryotic signal transduction than HK with respect to the duration and settling time of response signals. JF - Computational biology and chemistry SN - 1476-9271 AD - Interdisciplinary Program in Bioinformatics, Seoul National University, Gwanak-gu, Seoul 151-747, Republic of Korea; Department of Bio and Brain Engineering and KI for the BioCentury, Korea Advanced Institute of Science and Technology (KAIST), 335 Gwahangno, Yuseong-gu, Daejeon 305-701, Republic of Korea. TI - Why have serine/threonine/tyrosine kinases been evolutionarily selected in eukaryotic signaling cascades? KW - bioinformatics KW - evolution KW - kinase KW - signaling AU - Choi, Hyung-Seok AU - Kim, Jeong-Rae AU - Lee, Sang-Woo AU - Cho, Kwang-Hyun PY - 2008/02/23/ UR - http://dx.doi.org/10.1016/j.compbiolchem.2008.02.005 ER -