Evolution of protein kinase signaling from yeast to man

by: Gerard Manning, Gregory D Plowman, Tony Hunter, Sucha Sudarsanam

Trends in Biochemical Sciences, Vol. 27, No. 10. (1 October 2002), pp. 514-520.

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Abstract

Protein phosphorylation controls many cellular processes, especially those involved in intercellular communication and coordination of complex functions. To explore the evolution of protein phosphorylation, we compared the protein kinase complements ([`]kinomes') of budding yeast, worm and fly, with known human kinases. We classify kinases into putative orthologous groups with conserved functions and discuss kinase families and pathways that are unique, expanded or lost in each lineage. Fly and human share several kinase families involved in immunity, neurobiology, cell cycle and morphogenesis that are absent from worm, suggesting that these functions might have evolved after the divergence of nematodes from the main metazoan lineage.

@article{citeulike:2707968, abstract = {Protein phosphorylation controls many cellular processes, especially those involved in intercellular communication and coordination of complex functions. To explore the evolution of protein phosphorylation, we compared the protein kinase complements ([`]kinomes') of budding yeast, worm and fly, with known human kinases. We classify kinases into putative orthologous groups with conserved functions and discuss kinase families and pathways that are unique, expanded or lost in each lineage. Fly and human share several kinase families involved in immunity, neurobiology, cell cycle and morphogenesis that are absent from worm, suggesting that these functions might have evolved after the divergence of nematodes from the main metazoan lineage.}, author = {Manning, Gerard and Plowman, Gregory D. and Hunter, Tony and Sudarsanam, Sucha }, citeulike-article-id = {2707968}, doi = {http://dx.doi.org/10.1016/S0968-0004(02)02179-5}, journal = {Trends in Biochemical Sciences}, keywords = {evolution, kinase, kinome}, month = {October}, number = {10}, pages = {514--520}, posted-at = {2008-06-24 14:22:46}, priority = {2}, title = {Evolution of protein kinase signaling from yeast to man}, url = {http://dx.doi.org/10.1016/S0968-0004(02)02179-5}, volume = {27}, year = {2002} }

RIS record

TY - JOUR ID - citeulike:2707968 L3 - citeulike-article-id:2707968 N2 - Protein phosphorylation controls many cellular processes, especially those involved in intercellular communication and coordination of complex functions. To explore the evolution of protein phosphorylation, we compared the protein kinase complements ([`]kinomes') of budding yeast, worm and fly, with known human kinases. We classify kinases into putative orthologous groups with conserved functions and discuss kinase families and pathways that are unique, expanded or lost in each lineage. Fly and human share several kinase families involved in immunity, neurobiology, cell cycle and morphogenesis that are absent from worm, suggesting that these functions might have evolved after the divergence of nematodes from the main metazoan lineage. IS - 10 JF - Trends in Biochemical Sciences EP - 520 TI - Evolution of protein kinase signaling from yeast to man VL - 27 SP - 514 KW - evolution KW - kinase KW - kinome AU - Manning, Gerard AU - Plowman, Gregory AU - Hunter, Tony AU - Sudarsanam, Sucha PY - 2002/10/01/ UR - http://dx.doi.org/10.1016/S0968-0004(02)02179-5 ER -

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