Comparative genomics of the eukaryotes.

by: GM Rubin, MD Yandell, JR Wortman, GL Gabor Miklos, CR Nelson, IK Hariharan, ME Fortini, PW Li, R Apweiler, W Fleischmann, JM Cherry, S Henikoff, MP Skupski, S Misra, M Ashburner, E Birney, MS Boguski, T Brody, P Brokstein, SE Celniker, SA Chervitz, D Coates, A Cravchik, A Gabrielian, RF Galle, WM Gelbart, RA George, LS Goldstein, F Gong, P Guan, NL Harris, BA Hay, RA Hoskins, J Li, Z Li, RO Hynes, SJ Jones, PM Kuehl, B Lemaitre, JT Littleton, DK Morrison, C Mungall, PH O'Farrell, OK Pickeral, C Shue, LB Vosshall, J Zhang, Q Zhao, XH Zheng, S Lewis

Science, Vol. 287, No. 5461. (24 March 2000), pp. 2204-2215.

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Abstract

A comparative analysis of the genomes of Drosophila melanogaster, Caenorhabditis elegans, and Saccharomyces cerevisiae-and the proteins they are predicted to encode-was undertaken in the context of cellular, developmental, and evolutionary processes. The nonredundant protein sets of flies and worms are similar in size and are only twice that of yeast, but different gene families are expanded in each genome, and the multidomain proteins and signaling pathways of the fly and worm are far more complex than those of yeast. The fly has orthologs to 177 of the 289 human disease genes examined and provides the foundation for rapid analysis of some of the basic processes involved in human disease.

@article{citeulike:163543, abstract = {A comparative analysis of the genomes of Drosophila melanogaster, Caenorhabditis elegans, and Saccharomyces cerevisiae-and the proteins they are predicted to encode-was undertaken in the context of cellular, developmental, and evolutionary processes. The nonredundant protein sets of flies and worms are similar in size and are only twice that of yeast, but different gene families are expanded in each genome, and the multidomain proteins and signaling pathways of the fly and worm are far more complex than those of yeast. The fly has orthologs to 177 of the 289 human disease genes examined and provides the foundation for rapid analysis of some of the basic processes involved in human disease.}, address = {Howard Hughes Medical Institute, Department of Molecular and Cell Biology, Berkeley Drosophila Genome Project, University of California, Berkeley, CA 94720, USA.}, author = {Rubin, G. M. and Yandell, M. D. and Wortman, J. R. and Gabor Miklos, G. L. and Nelson, C. R. and Hariharan, I. K. and Fortini, M. E. and Li, P. W. and Apweiler, R. and Fleischmann, W. and Cherry, J. M. and Henikoff, S. and Skupski, M. P. and Misra, S. and Ashburner, M. and Birney, E. and Boguski, M. S. and Brody, T. and Brokstein, P. and Celniker, S. E. and Chervitz, S. A. and Coates, D. and Cravchik, A. and Gabrielian, A. and Galle, R. F. and Gelbart, W. M. and George, R. A. and Goldstein, L. S. and Gong, F. and Guan, P. and Harris, N. L. and Hay, B. A. and Hoskins, R. A. and Li, J. and Li, Z. and Hynes, R. O. and Jones, S. J. and Kuehl, P. M. and Lemaitre, B. and Littleton, J. T. and Morrison, D. K. and Mungall, C. and O'Farrell, P. H. and Pickeral, O. K. and Shue, C. and Vosshall, L. B. and Zhang, J. and Zhao, Q. and Zheng, X. H. and Lewis, S. }, citeulike-article-id = {163543}, doi = {http://dx.doi.org/10.1126/science.287.5461.2204}, issn = {0036-8075}, journal = {Science}, keywords = {evolution, genome}, month = {March}, number = {5461}, pages = {2204--2215}, posted-at = {2008-06-24 14:25:51}, priority = {2}, title = {Comparative genomics of the eukaryotes.}, url = {http://dx.doi.org/10.1126/science.287.5461.2204}, volume = {287}, year = {2000} }

RIS record

TY - JOUR ID - citeulike:163543 L3 - citeulike-article-id:163543 N2 - A comparative analysis of the genomes of Drosophila melanogaster, Caenorhabditis elegans, and Saccharomyces cerevisiae-and the proteins they are predicted to encode-was undertaken in the context of cellular, developmental, and evolutionary processes. The nonredundant protein sets of flies and worms are similar in size and are only twice that of yeast, but different gene families are expanded in each genome, and the multidomain proteins and signaling pathways of the fly and worm are far more complex than those of yeast. The fly has orthologs to 177 of the 289 human disease genes examined and provides the foundation for rapid analysis of some of the basic processes involved in human disease. IS - 5461 JF - Science SN - 0036-8075 AD - Howard Hughes Medical Institute, Department of Molecular and Cell Biology, Berkeley Drosophila Genome Project, University of California, Berkeley, CA 94720, USA. EP - 2215 TI - Comparative genomics of the eukaryotes. VL - 287 SP - 2204 KW - evolution KW - genome AU - Rubin, GM AU - Yandell, MD AU - Wortman, JR AU - Gabor Miklos, GL AU - Nelson, CR AU - Hariharan, IK AU - Fortini, ME AU - Li, PW AU - Apweiler, R AU - Fleischmann, W AU - Cherry, JM AU - Henikoff, S AU - Skupski, MP AU - Misra, S AU - Ashburner, M AU - Birney, E AU - Boguski, MS AU - Brody, T AU - Brokstein, P AU - Celniker, SE AU - Chervitz, SA AU - Coates, D AU - Cravchik, A AU - Gabrielian, A AU - Galle, RF AU - Gelbart, WM AU - George, RA AU - Goldstein, LS AU - Gong, F AU - Guan, P AU - Harris, NL AU - Hay, BA AU - Hoskins, RA AU - Li, J AU - Li, Z AU - Hynes, RO AU - Jones, SJ AU - Kuehl, PM AU - Lemaitre, B AU - Littleton, JT AU - Morrison, DK AU - Mungall, C AU - O'Farrell, PH AU - Pickeral, OK AU - Shue, C AU - Vosshall, LB AU - Zhang, J AU - Zhao, Q AU - Zheng, XH AU - Lewis, S PY - 2000/03/24/ UR - http://dx.doi.org/10.1126/science.287.5461.2204 ER -

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