Controlling the false positive rate in fuzzy clustering using randomization: application to fMRI activation detection

@article{citeulike:1642744, abstract = {Despite its potential advantages for fMRI analysis, fuzzy C-means (FCM) clustering suffers from limitations such as the need for a priori knowledge of the number of clusters, and unknown statistical significance and instability of the results. We propose a randomization-based method to control the false-positive rate and estimate statistical significance of the FCM results. Using this novel approach, we develop an fMRI activation detection method. The ability of the method in controlling the false-positive rate is shown by analysis of false positives in activation maps of resting-state fMRI data. Controlling the false-positive rate in FCM allows comparison of different fuzzy clustering methods, using different feature spaces, to other fMRI detection methods. In this article, using simulation and real fMRI data, we compare a novel feature space that takes the variability of the hemodynamic response function into account (HRF-based feature space) to the conventional cross-correlation analysis and FCM using the cross-correlation feature space. In both cases, the HRF-based feature space provides a greater sensitivity compared to the cross-correlation feature space and conventional cross-correlation analysis. Application of the proposed method to finger-tapping fMRI data, using HRF-based feature space, detected activation in sub-cortical regions, whereas both of the FCM with cross-correlation feature space and the conventional cross-correlation method failed to detect them.}, author = {Jahanian, Hesamoddin and Hossein-Zadeh, Gholam-Ali and Soltanian-Zadeh, Hamid and Ardekani, Babak A. }, citeulike-article-id = {1642744}, doi = {http://dx.doi.org/10.1016/j.mri.2004.01.035}, journal = {Magnetic Resonance Imaging}, keywords = {activation, clustering, fmri, fnak, permutation}, month = {June}, number = {5}, pages = {631--638}, posted-at = {2007-09-10 19:42:00}, priority = {5}, title = {Controlling the false positive rate in fuzzy clustering using randomization: application to fMRI activation detection}, url = {http://dx.doi.org/10.1016/j.mri.2004.01.035}, volume = {22}, year = {2004} }

TY - JOUR ID - citeulike:1642744 L3 - citeulike-article-id:1642744 TI - Controlling the false positive rate in fuzzy clustering using randomization: application to fMRI activation detection JF - Magnetic Resonance Imaging VL - 22 IS - 5 SP - 631 EP - 638 N2 - Despite its potential advantages for fMRI analysis, fuzzy C-means (FCM) clustering suffers from limitations such as the need for a priori knowledge of the number of clusters, and unknown statistical significance and instability of the results. We propose a randomization-based method to control the false-positive rate and estimate statistical significance of the FCM results. Using this novel approach, we develop an fMRI activation detection method. The ability of the method in controlling the false-positive rate is shown by analysis of false positives in activation maps of resting-state fMRI data. Controlling the false-positive rate in FCM allows comparison of different fuzzy clustering methods, using different feature spaces, to other fMRI detection methods. In this article, using simulation and real fMRI data, we compare a novel feature space that takes the variability of the hemodynamic response function into account (HRF-based feature space) to the conventional cross-correlation analysis and FCM using the cross-correlation feature space. In both cases, the HRF-based feature space provides a greater sensitivity compared to the cross-correlation feature space and conventional cross-correlation analysis. Application of the proposed method to finger-tapping fMRI data, using HRF-based feature space, detected activation in sub-cortical regions, whereas both of the FCM with cross-correlation feature space and the conventional cross-correlation method failed to detect them. KW - activation KW - clustering KW - fmri KW - fnak KW - permutation AU - Jahanian, Hesamoddin AU - Hossein-Zadeh, Gholam-Ali AU - Soltanian-Zadeh, Hamid AU - Ardekani, Babak PY - 2004/06// UR - http://dx.doi.org/10.1016/j.mri.2004.01.035 ER -