How repeated retroelements format genome function.

@article{citeulike:2795045, abstract = {Genomes operate as sophisticated information storage systems. Generic repeated signals in the DNA format expression of coding sequence files and organize additional functions essential for genome replication and accurate transmission to progeny cells. Retroelements comprise a major fraction of many genomes and contain a surprising diversity of functional signals. In this article, we summarize some features of the taxonomic distribution of retroelements, especially mammalian SINEs, tabulate functional roles documented for different classes of retroelements, and discuss their potential roles as genome organizers. In particular, the fact that certain retroelements serve as boundaries for heterochromatin domains and provide a significant fraction of scaffolding/matrix attachment regions (S/MARs) suggests that the reversed transcribed component of the genome plays a major architectonic role in higher order physical structuring. Employing an information science model, the "functionalist" perspective on repetitive DNA leads to new ways of thinking about the systemic organization of cellular genomes and provides several novel possibilities involving retroelements in evolutionarily significant genome reorganization.}, address = {National Center for Biotechnology Information, National Institutes of Health, Bethesda, MD, USA.}, author = {von Sternberg, R. and Shapiro, J. A. }, citeulike-article-id = {2795045}, doi = {10.1159/000084942}, issn = {1424-859X}, journal = {Cytogenetic and genome research}, keywords = {doctorate, genomics, transposon}, number = {1-4}, pages = {108--116}, posted-at = {2008-05-13 14:45:41}, priority = {2}, title = {How repeated retroelements format genome function.}, url = {http://dx.doi.org/10.1159/000084942}, volume = {110}, year = {2005} }

TY - JOUR ID - citeulike:2795045 L3 - citeulike-article-id:2795045 TI - How repeated retroelements format genome function. JF - Cytogenetic and genome research VL - 110 IS - 1-4 SP - 108 EP - 116 AD - National Center for Biotechnology Information, National Institutes of Health, Bethesda, MD, USA. SN - 1424-859X N2 - Genomes operate as sophisticated information storage systems. Generic repeated signals in the DNA format expression of coding sequence files and organize additional functions essential for genome replication and accurate transmission to progeny cells. Retroelements comprise a major fraction of many genomes and contain a surprising diversity of functional signals. In this article, we summarize some features of the taxonomic distribution of retroelements, especially mammalian SINEs, tabulate functional roles documented for different classes of retroelements, and discuss their potential roles as genome organizers. In particular, the fact that certain retroelements serve as boundaries for heterochromatin domains and provide a significant fraction of scaffolding/matrix attachment regions (S/MARs) suggests that the reversed transcribed component of the genome plays a major architectonic role in higher order physical structuring. Employing an information science model, the "functionalist" perspective on repetitive DNA leads to new ways of thinking about the systemic organization of cellular genomes and provides several novel possibilities involving retroelements in evolutionarily significant genome reorganization. KW - doctorate KW - genomics KW - transposon AU - von Sternberg, R AU - Shapiro, JA PY - 2005/// UR - http://dx.doi.org/10.1159/000084942 ER -