Long-term N-acetylcysteine and L-arginine administration reduces endothelial activation and systolic blood pressure in hypertensive patients with type 2 diabetes.

@article{citeulike:2776508, abstract = {OBJECTIVE: Reactive oxygen and nitric oxide (NO) have recently been considered to be involved in the cardiovascular complications of patients with type 2 diabetes, as NO is thought to lose its beneficial physiological effects in the presence of oxygen radicals. For this reason, we tested the effects of l-arginine (ARG) and N-acetylcysteine (NAC) administration in increasing NO bioavailability by reducing free radical formation. RESEARCH DESIGN AND METHODS: A double-blind study was performed on 24 male patients with type 2 diabetes and hypertension divided into two groups of 12 patients that randomly received either an oral supplementation of placebo or NAC + ARG for 6 months. RESULTS: The NAC + ARG treatment caused a reduction of both systolic (P < 0.05) and diastolic (P < 0.05) mean arterial blood pressure, total cholesterol (P < 0.01), LDL cholesterol (P < 0.005), oxidized LDL (P < 0.05), high-sensitive C-reactive protein (P < 0.05), intracellular adhesion molecule (P < 0.05), vascular cell adhesion molecule (P < 0.01), nitrotyrosine (P < 0.01), fibrinogen (P < 0.01), and plasminogen activator inhibitor-1 (P < 0.05), and an improvement of the intima-media thickness during endothelial postischemic vasodilation (P < 0.02). HDL cholesterol increased (P < 0.05). No changes in other parameters studied were observed. CONCLUSIONS: NAC + ARG administration seems to be a potential well-tolerated antiatherogenic therapy because it improves endothelial function in hypertensive patients with type 2 diabetes by improving NO bioavailability via reduction of oxidative stress and increase of NO production. Our study's results give prominence to its potential use in primary and secondary cardiovascular prevention in these patients.}, address = {Department of Internal Medicine, University of Torino, Corso Dogliotti 14, I-10121 Torino, Italy. valentino.martina@unito.it}, author = {Martina, V. and Masha, A. and Gigliardi, V. R. and Brocato, L. and Manzato, E. and Berchio, A. and Massarenti, P. and Settanni, F. and Della Casa, L. and Bergamini, S. and Iannone, A. }, citeulike-article-id = {2776508}, doi = {10.2337/dc07-2251}, issn = {1935-5548}, journal = {Diabetes care}, keywords = {diabetes, hta, rct, vasculardisease}, month = {May}, number = {5}, pages = {940--944}, posted-at = {2008-05-09 20:40:09}, priority = {2}, title = {Long-term N-acetylcysteine and L-arginine administration reduces endothelial activation and systolic blood pressure in hypertensive patients with type 2 diabetes.}, url = {http://dx.doi.org/10.2337/dc07-2251}, volume = {31}, year = {2008} }

TY - JOUR ID - citeulike:2776508 L3 - citeulike-article-id:2776508 TI - Long-term N-acetylcysteine and L-arginine administration reduces endothelial activation and systolic blood pressure in hypertensive patients with type 2 diabetes. JF - Diabetes care VL - 31 IS - 5 SP - 940 EP - 944 AD - Department of Internal Medicine, University of Torino, Corso Dogliotti 14, I-10121 Torino, Italy. valentino.martina@unito.it SN - 1935-5548 N2 - OBJECTIVE: Reactive oxygen and nitric oxide (NO) have recently been considered to be involved in the cardiovascular complications of patients with type 2 diabetes, as NO is thought to lose its beneficial physiological effects in the presence of oxygen radicals. For this reason, we tested the effects of l-arginine (ARG) and N-acetylcysteine (NAC) administration in increasing NO bioavailability by reducing free radical formation. RESEARCH DESIGN AND METHODS: A double-blind study was performed on 24 male patients with type 2 diabetes and hypertension divided into two groups of 12 patients that randomly received either an oral supplementation of placebo or NAC + ARG for 6 months. RESULTS: The NAC + ARG treatment caused a reduction of both systolic (P < 0.05) and diastolic (P < 0.05) mean arterial blood pressure, total cholesterol (P < 0.01), LDL cholesterol (P < 0.005), oxidized LDL (P < 0.05), high-sensitive C-reactive protein (P < 0.05), intracellular adhesion molecule (P < 0.05), vascular cell adhesion molecule (P < 0.01), nitrotyrosine (P < 0.01), fibrinogen (P < 0.01), and plasminogen activator inhibitor-1 (P < 0.05), and an improvement of the intima-media thickness during endothelial postischemic vasodilation (P < 0.02). HDL cholesterol increased (P < 0.05). No changes in other parameters studied were observed. CONCLUSIONS: NAC + ARG administration seems to be a potential well-tolerated antiatherogenic therapy because it improves endothelial function in hypertensive patients with type 2 diabetes by improving NO bioavailability via reduction of oxidative stress and increase of NO production. Our study's results give prominence to its potential use in primary and secondary cardiovascular prevention in these patients. KW - diabetes KW - hta KW - rct KW - vasculardisease AU - Martina, V AU - Masha, A AU - Gigliardi, VR AU - Brocato, L AU - Manzato, E AU - Berchio, A AU - Massarenti, P AU - Settanni, F AU - Della Casa, L AU - Bergamini, S AU - Iannone, A PY - 2008/05// UR - http://dx.doi.org/10.2337/dc07-2251 ER -