N of 1 trials in diabetes: making individual therapeutic decisions

by: A Tsapas, D Matthews

Diabetologia, Vol. 51, No. 6. (1 June 2008), pp. 921-925.

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Abstract

Abstract N of 1 trials are single-subject, randomised, crossover studies, in which the patient serves as their own control to compare the efficacy of a treatment. They offer an alternative to large, randomised clinical trials, which have limited applicability, and empirical testing, which is arbitrary in nature. N of 1 trials are regarded as providing the highest strength of evidence for individual subject decisions. They rely upon the patient expressing preferences and making shared decisions for determining the future therapy, and may therefore lead to the successful implementation of lifestyle interventions. N of 1 trials are an optimal approach for making therapeutic decisions in chronic diseases like diabetes mellitus, where decision-making is often reliant upon arbitrary criteria and clinical judgement.

@article{citeulike:2754800, abstract = {Abstract\ \  N of 1 trials are single-subject, randomised, crossover studies, in which the patient serves as their own control to compare the efficacy of a treatment. They offer an alternative to large, randomised clinical trials, which have limited applicability, and empirical testing, which is arbitrary in nature. N of 1 trials are regarded as providing the highest strength of evidence for individual subject decisions. They rely upon the patient expressing preferences and making shared decisions for determining the future therapy, and may therefore lead to the successful implementation of lifestyle interventions. N of 1 trials are an optimal approach for making therapeutic decisions in chronic diseases like diabetes mellitus, where decision-making is often reliant upon arbitrary criteria and clinical judgement.}, author = {Tsapas, A. and Matthews, D. }, citeulike-article-id = {2754800}, doi = {10.1007/s00125-008-0983-2}, journal = {Diabetologia}, keywords = {diabetes, therapy}, month = {June}, number = {6}, pages = {921--925}, posted-at = {2008-05-05 02:40:07}, priority = {2}, title = {N of 1 trials in diabetes: making individual therapeutic decisions}, url = {http://dx.doi.org/10.1007/s00125-008-0983-2}, volume = {51}, year = {2008} }

RIS record

TY - JOUR ID - citeulike:2754800 TI - N of 1 trials in diabetes: making individual therapeutic decisions JF - Diabetologia VL - 51 IS - 6 SP - 921 EP - 925 N2 - Abstract   N of 1 trials are single-subject, randomised, crossover studies, in which the patient serves as their own control to compare the efficacy of a treatment. They offer an alternative to large, randomised clinical trials, which have limited applicability, and empirical testing, which is arbitrary in nature. N of 1 trials are regarded as providing the highest strength of evidence for individual subject decisions. They rely upon the patient expressing preferences and making shared decisions for determining the future therapy, and may therefore lead to the successful implementation of lifestyle interventions. N of 1 trials are an optimal approach for making therapeutic decisions in chronic diseases like diabetes mellitus, where decision-making is often reliant upon arbitrary criteria and clinical judgement. KW - diabetes KW - therapy AU - Tsapas, A AU - Matthews, D PY - 2008/06/01/ UR - http://dx.doi.org/10.1007/s00125-008-0983-2 ER -

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