Variations in the uncoupling protein-3 gene are associated with specific obesity phenotypes

@article{citeulike:2697905, abstract = {ObjectiveUncoupling protein 3 (UCP-3) uncouples oxidative metabolism from ATP synthesis, resulting in the production of heat instead of energy storage. Single nucleotide polymorphisms (SNPs) in UCP-3 might result in a reduced function or expression of UCP-3 and therefore lead to an increased capacity to store energy as fat. DesignWe conducted a population-based, cross-sectional single-center study among 400 Dutch men between 40 and 80 years. MethodsSeven SNPs in the UCP-3 gene were genotyped by means of an allele-specific real-time TaqMan PCR. Linear regression analyses were performed to examine the independent effects of these SNPs on obesity phenotypes. ResultsWe found a significant association between homozygosity for the minor allele of rs647126, rs1685356, and rs2075577 and an increase in body mass index (BMI; P=0.033, P=0.016, and P=0.019 respectively). Heterozygosity for rs1685354 was associated with a significant decrease in visceral fat mass (P=0.030). ConclusionsOur results suggest that genetic variations in the UCP-3 gene are associated with an increase in BMI. A plausible mechanism by which these SNPs lead to an increase in BMI is that due to these SNPs, the UCP-3 activity might be decreased. As a result, uncoupling activity may also decrease, which will lead to an increase in body weight and BMI. 10.1530/EJE-07-0834}, author = {van Abeelen, Annet F. and de Krom, Mariken and Hendriks, Judith and Grobbee, Diederick E. and Adan, Roger A. and van der Schouw, Yvonne T. }, citeulike-article-id = {2697905}, doi = {10.1530/EJE-07-0834}, journal = {Eur J Endocrinol}, keywords = {diagnosis, molecular, obesity}, month = {May}, number = {5}, pages = {669--676}, posted-at = {2008-04-21 20:11:16}, priority = {2}, title = {Variations in the uncoupling protein-3 gene are associated with specific obesity phenotypes}, url = {http://dx.doi.org/10.1530/EJE-07-0834}, volume = {158}, year = {2008} }

TY - JOUR ID - citeulike:2697905 TI - Variations in the uncoupling protein-3 gene are associated with specific obesity phenotypes JF - Eur J Endocrinol VL - 158 IS - 5 SP - 669 EP - 676 N2 - ObjectiveUncoupling protein 3 (UCP-3) uncouples oxidative metabolism from ATP synthesis, resulting in the production of heat instead of energy storage. Single nucleotide polymorphisms (SNPs) in UCP-3 might result in a reduced function or expression of UCP-3 and therefore lead to an increased capacity to store energy as fat. DesignWe conducted a population-based, cross-sectional single-center study among 400 Dutch men between 40 and 80 years. MethodsSeven SNPs in the UCP-3 gene were genotyped by means of an allele-specific real-time TaqMan PCR. Linear regression analyses were performed to examine the independent effects of these SNPs on obesity phenotypes. ResultsWe found a significant association between homozygosity for the minor allele of rs647126, rs1685356, and rs2075577 and an increase in body mass index (BMI; P=0.033, P=0.016, and P=0.019 respectively). Heterozygosity for rs1685354 was associated with a significant decrease in visceral fat mass (P=0.030). ConclusionsOur results suggest that genetic variations in the UCP-3 gene are associated with an increase in BMI. A plausible mechanism by which these SNPs lead to an increase in BMI is that due to these SNPs, the UCP-3 activity might be decreased. As a result, uncoupling activity may also decrease, which will lead to an increase in body weight and BMI. 10.1530/EJE-07-0834 KW - diagnosis KW - molecular KW - obesity AU - van Abeelen, Annet AU - de Krom, Mariken AU - Hendriks, Judith AU - Grobbee, Diederick AU - Adan, Roger AU - van der Schouw, Yvonne PY - 2008/05/01/ UR - http://dx.doi.org/10.1530/EJE-07-0834 ER -