Testosterone administration to men increases hepatic lipase activity and decreases HDL and LDL size in 3 wk

@article{citeulike:2323185, abstract = {Testosterone administration to men is known to decrease high-density lipoprotein cholesterol (HDL-C) and the subclasses HDL2 and HDL3. It also might increase the number of small, dense, low-density lipoprotein cholesterol (LDL-C) particles in hypogonadal men. The decrease in HDL-C and in LDL-C size is potentially mediated by hepatic lipase activity, which hydrolyzes lipoprotein phospholipids and triacylglycerol. To determine how HDL-C and LDL-C particles are affected by testosterone administration to eugonadal men, testosterone was administered as a supraphysiological dose (600 mg/wk) for 3 wk to elderly, obese, eugonadal men before elective hip or knee surgery, and lipids were measured by routine methods and by density gradient ultracentrifugation. Hepatic lipase activity increased >60\% above baseline levels, and HDL-C, HDL2, and HDL3 significantly declined in 3 wk. In addition, the LDL-C peak particle density and the amount of LDL-C significantly increased. Testosterone is therefore a potent stimulator of hepatic lipase activity, decreasing HDL-C, HDL2, and HDL3 as well as increasing LDL particle density changes, all associated with increased cardiovascular risk. 10.1152/ajpendo.00524.2002}, author = {Herbst, Karen L. and Amory, John K. and Brunzell, John D. and Chansky, Howard A. and Bremner, William J. }, citeulike-article-id = {2323185}, comment = {Es de anotar que hay un evidente cambio en las fracciones de HDL y LDL (samller denser); pero a dosis suprafisologicas (TE 600 mg/sem)}, doi = {http://dx.doi.org/10.1152/ajpendo.00524.2002}, journal = {Am J Physiol Endocrinol Metab}, keywords = {aging, hplp, physiology, rct, testosterone}, month = {June}, number = {6}, pages = {E1112--1118}, posted-at = {2008-02-02 15:12:58}, priority = {2}, title = {Testosterone administration to men increases hepatic lipase activity and decreases HDL and LDL size in 3 wk}, url = {http://dx.doi.org/10.1152/ajpendo.00524.2002}, volume = {284}, year = {2003} }

TY - JOUR ID - citeulike:2323185 L3 - citeulike-article-id:2323185 TI - Testosterone administration to men increases hepatic lipase activity and decreases HDL and LDL size in 3 wk JF - Am J Physiol Endocrinol Metab VL - 284 IS - 6 SP - E1112 EP - 1118 N2 - Testosterone administration to men is known to decrease high-density lipoprotein cholesterol (HDL-C) and the subclasses HDL2 and HDL3. It also might increase the number of small, dense, low-density lipoprotein cholesterol (LDL-C) particles in hypogonadal men. The decrease in HDL-C and in LDL-C size is potentially mediated by hepatic lipase activity, which hydrolyzes lipoprotein phospholipids and triacylglycerol. To determine how HDL-C and LDL-C particles are affected by testosterone administration to eugonadal men, testosterone was administered as a supraphysiological dose (600 mg/wk) for 3 wk to elderly, obese, eugonadal men before elective hip or knee surgery, and lipids were measured by routine methods and by density gradient ultracentrifugation. Hepatic lipase activity increased >60% above baseline levels, and HDL-C, HDL2, and HDL3 significantly declined in 3 wk. In addition, the LDL-C peak particle density and the amount of LDL-C significantly increased. Testosterone is therefore a potent stimulator of hepatic lipase activity, decreasing HDL-C, HDL2, and HDL3 as well as increasing LDL particle density changes, all associated with increased cardiovascular risk. 10.1152/ajpendo.00524.2002 KW - aging KW - hplp KW - physiology KW - rct KW - testosterone N1 - Es de anotar que hay un evidente cambio en las fracciones de HDL y LDL (samller denser); pero a dosis suprafisologicas (TE 600 mg/sem) AU - Herbst, Karen AU - Amory, John AU - Brunzell, John AU - Chansky, Howard AU - Bremner, William PY - 2003/06/01/ UR - http://dx.doi.org/10.1152/ajpendo.00524.2002 ER -