The effects of supraphysiologic doses of testosterone on muscle size and strength in normal men.

@article{citeulike:2295258, abstract = {BACKGROUND: Athletes often take androgenic steroids in an attempt to increase their strength. The efficacy of these substances for this purpose is unsubstantiated, however. METHODS: We randomly assigned 43 normal men to one of four groups: placebo with no exercise; testosterone with no exercise; placebo plus exercise; and testosterone plus exercise. The men received injections of 600 mg of testosterone enanthate or placebo weekly for 10 weeks. The men in the exercise groups performed standardized weight-lifting exercises three times weekly. Before and after the treatment period, fat-free mass was determined by underwater weighing, muscle size was measured by magnetic resonance imaging, and the strength of the arms and legs was assessed by bench-press and squatting exercises, respectively. RESULTS: Among the men in the no-exercise groups, those given testosterone had greater increases than those given placebo in muscle size in their arms (mean [+/-SE] change in triceps area, 424 +/- 104 vs. -81 +/- 109 square millimeters; P < 0.05) and legs (change in quadriceps area, 607 +/- 123 vs. -131 +/- 111 square millimeters; P < 0.05) and greater increases in strength in the bench-press (9 +/- 4 vs. -1 +/- 1 kg, P < 0.05) and squatting exercises (16 +/- 4 vs. 3 +/- 1 kg, P < 0.05). The men assigned to testosterone and exercise had greater increases in fat-free mass (6.1 +/- 0.6 kg) and muscle size (triceps area, 501 +/- 104 square millimeters; quadriceps area, 1174 +/- 91 square millimeters) than those assigned to either no-exercise group, and greater increases in muscle strength (bench-press strength, 22 +/- 2 kg; squatting-exercise capacity, 38 +/- 4 kg) than either no-exercise group. Neither mood nor behavior was altered in any group. CONCLUSIONS: Supraphysiologic doses of testosterone, especially when combined with strength training, increase fat-free mass and muscle size and strength in normal men.}, address = {Department of Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, CA 90059, USA.}, author = {Bhasin, S. and Storer, T. W. and Berman, N. and Callegari, C. and Clevenger, B. and Phillips, J. and Bunnell, T. J. and Tricker, R. and Shirazi, A. and Casaburi, R. }, citeulike-article-id = {2295258}, comment = {Lo interesante del articulo es que se usaron dosis de 600 mg/c/10 dias*10 semanas de TE con evidente efecto sobre variables de composicion corporal y efecto neutro sobre parametros de lipidos. Es de interes su aplicacion en contexto de pacientes con sarcopenia}, issn = {0028-4793}, journal = {N Engl J Med}, keywords = {androgen, excercise, malegonadal, physiology, testosterone, therapy}, month = {July}, number = {1}, pages = {1--7}, posted-at = {2008-01-27 19:13:44}, priority = {2}, title = {The effects of supraphysiologic doses of testosterone on muscle size and strength in normal men.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/8637535}, volume = {335}, year = {1996} }

TY - JOUR ID - citeulike:2295258 L3 - citeulike-article-id:2295258 TI - The effects of supraphysiologic doses of testosterone on muscle size and strength in normal men. JF - N Engl J Med VL - 335 IS - 1 SP - 1 EP - 7 AD - Department of Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, CA 90059, USA. SN - 0028-4793 N2 - BACKGROUND: Athletes often take androgenic steroids in an attempt to increase their strength. The efficacy of these substances for this purpose is unsubstantiated, however. METHODS: We randomly assigned 43 normal men to one of four groups: placebo with no exercise; testosterone with no exercise; placebo plus exercise; and testosterone plus exercise. The men received injections of 600 mg of testosterone enanthate or placebo weekly for 10 weeks. The men in the exercise groups performed standardized weight-lifting exercises three times weekly. Before and after the treatment period, fat-free mass was determined by underwater weighing, muscle size was measured by magnetic resonance imaging, and the strength of the arms and legs was assessed by bench-press and squatting exercises, respectively. RESULTS: Among the men in the no-exercise groups, those given testosterone had greater increases than those given placebo in muscle size in their arms (mean [+/-SE] change in triceps area, 424 +/- 104 vs. -81 +/- 109 square millimeters; P < 0.05) and legs (change in quadriceps area, 607 +/- 123 vs. -131 +/- 111 square millimeters; P < 0.05) and greater increases in strength in the bench-press (9 +/- 4 vs. -1 +/- 1 kg, P < 0.05) and squatting exercises (16 +/- 4 vs. 3 +/- 1 kg, P < 0.05). The men assigned to testosterone and exercise had greater increases in fat-free mass (6.1 +/- 0.6 kg) and muscle size (triceps area, 501 +/- 104 square millimeters; quadriceps area, 1174 +/- 91 square millimeters) than those assigned to either no-exercise group, and greater increases in muscle strength (bench-press strength, 22 +/- 2 kg; squatting-exercise capacity, 38 +/- 4 kg) than either no-exercise group. Neither mood nor behavior was altered in any group. CONCLUSIONS: Supraphysiologic doses of testosterone, especially when combined with strength training, increase fat-free mass and muscle size and strength in normal men. KW - androgen KW - excercise KW - malegonadal KW - physiology KW - testosterone KW - therapy N1 - Lo interesante del articulo es que se usaron dosis de 600 mg/c/10 dias*10 semanas de TE con evidente efecto sobre variables de composicion corporal y efecto neutro sobre parametros de lipidos. Es de interes su aplicacion en contexto de pacientes con sarcopenia AU - Bhasin, S AU - Storer, TW AU - Berman, N AU - Callegari, C AU - Clevenger, B AU - Phillips, J AU - Bunnell, TJ AU - Tricker, R AU - Shirazi, A AU - Casaburi, R PY - 1996/07/04/ UR - http://view.ncbi.nlm.nih.gov/pubmed/8637535 ER -