Association of SHBG gene polymorphism with menarche.

@article{citeulike:2220179, abstract = {The age of menarche may be subject to hereditary influences but the specific determinants are unknown. Our aim was to investigate the possible association of a functional (TAAAA)n polymorphism in the promoter of the sex hormone-binding globulin (SHBG) gene with the timing of menarche. This polymorphism has been associated with polycystic ovary syndrome (PCOS) and is considered to contribute to SHBG levels. We studied 130 healthy normal-weight adolescent females from a closed community in North-Western Greece. Information on menarche was obtained through interviews. The BMI was recorded. Genomic DNA was isolated from peripheral blood leukocytes for genotyping the TAAAA repeat region. We subdivided our subjects into two groups based on median age of menarche: those with menarche <13 years and those with menarche > or =13 years. Genotype analysis revealed six (TAAAA)n alleles containing 5-10 TAAAA repeats. The distribution of alleles was different in the two groups. Girls with late menarche had more frequently longer TAAAA alleles (>8 repeats), while girls with early menarche had shorter alleles at a greater frequency (P=0.048). The major contribution to early menarche was by the 6 TAAAA repeat allele. Furthermore, carriers of the longer allele genotypes had later menarche (13.24+/-1.15 years) than those with shorter allele genotypes (12.67+/-1.15, P=0.018). These findings provide evidence for a genetic contribution of SHBG gene to the age of menarche.}, address = {Department of Endocrinology and Laboratory of Reproductive Genetics, University of Ioannina, Ioannina, Greece.}, author = {Xita, N. and Tsatsoulis, A. and Stavrou, I. and Georgiou, I. }, citeulike-article-id = {2220179}, comment = {Se sugiere que genotipos largos tienen menor actividad transcripcional del promotor y menopausia mas tard\'{i}a. Tendr\'{i}an igualmente menores niveles de SHBP, pero no la determinaron. Este polimorfismo funcional (TAAAA) del promotor ha sido asociado con PCO y contribuir\'{i}a a deiferencias en niveles sericos de SHBG}, issn = {1360-9947}, journal = {Mol Hum Reprod}, keywords = {femalegonadal, molecular, pco, shbg}, month = {June}, number = {6}, pages = {459--462}, posted-at = {2008-01-11 17:21:09}, priority = {2}, title = {Association of SHBG gene polymorphism with menarche.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/15879463}, volume = {11}, year = {2005} }

TY - JOUR ID - citeulike:2220179 L3 - citeulike-article-id:2220179 TI - Association of SHBG gene polymorphism with menarche. JF - Mol Hum Reprod VL - 11 IS - 6 SP - 459 EP - 462 AD - Department of Endocrinology and Laboratory of Reproductive Genetics, University of Ioannina, Ioannina, Greece. SN - 1360-9947 N2 - The age of menarche may be subject to hereditary influences but the specific determinants are unknown. Our aim was to investigate the possible association of a functional (TAAAA)n polymorphism in the promoter of the sex hormone-binding globulin (SHBG) gene with the timing of menarche. This polymorphism has been associated with polycystic ovary syndrome (PCOS) and is considered to contribute to SHBG levels. We studied 130 healthy normal-weight adolescent females from a closed community in North-Western Greece. Information on menarche was obtained through interviews. The BMI was recorded. Genomic DNA was isolated from peripheral blood leukocytes for genotyping the TAAAA repeat region. We subdivided our subjects into two groups based on median age of menarche: those with menarche <13 years and those with menarche > or =13 years. Genotype analysis revealed six (TAAAA)n alleles containing 5-10 TAAAA repeats. The distribution of alleles was different in the two groups. Girls with late menarche had more frequently longer TAAAA alleles (>8 repeats), while girls with early menarche had shorter alleles at a greater frequency (P=0.048). The major contribution to early menarche was by the 6 TAAAA repeat allele. Furthermore, carriers of the longer allele genotypes had later menarche (13.24+/-1.15 years) than those with shorter allele genotypes (12.67+/-1.15, P=0.018). These findings provide evidence for a genetic contribution of SHBG gene to the age of menarche. KW - femalegonadal KW - molecular KW - pco KW - shbg N1 - Se sugiere que genotipos largos tienen menor actividad transcripcional del promotor y menopausia mas tardía. Tendrían igualmente menores niveles de SHBP, pero no la determinaron. Este polimorfismo funcional (TAAAA) del promotor ha sido asociado con PCO y contribuiría a deiferencias en niveles sericos de SHBG AU - Xita, N AU - Tsatsoulis, A AU - Stavrou, I AU - Georgiou, I PY - 2005/06// UR - http://view.ncbi.nlm.nih.gov/pubmed/15879463 ER -