Approach to the Prostate Cancer Patient with Bone Disease

@article{citeulike:2216540, abstract = {Prostate cancer is the most common visceral malignancy in men. Androgen deprivation therapy (ADT) is commonly used in patients with nonmetastatic prostate cancer and is associated with significant bone loss and fractures. The greatest bone loss occurs during initiation of ADT. Men should have assessment of skeletal integrity with bone mineral density examination by dual x-ray absorptiometry of the hip and spine. Men with fragility fractures or osteoporosis by bone density should be considered for bisphosphonate therapy. Men with low bone mass may need antiresorptive therapy, depending on other risk factors. Men with a normal bone mineral density should be followed up closely with bone densitometry while on ADT. All men should receive preventive measures with calcium (1200 mg daily in divided doses), vitamin D (8001000 IU/d), and weight-bearing exercise. Men should be evaluated for additional secondary causes of bone loss including vitamin D insufficiency. Guidelines are needed for androgen-induced bone loss screening and treatment. 10.1210/jc.2007-1402}, author = {Greenspan, Susan L. }, citeulike-article-id = {2216540}, doi = {http://dx.doi.org/10.1210/jc.2007-1402}, journal = {J Clin Endocrinol Metab}, keywords = {cancer, osteoporosis, sideffects}, month = {January}, number = {1}, pages = {2--7}, posted-at = {2008-01-10 22:59:47}, priority = {2}, title = {Approach to the Prostate Cancer Patient with Bone Disease}, url = {http://dx.doi.org/10.1210/jc.2007-1402}, volume = {93}, year = {2008} }

TY - JOUR ID - citeulike:2216540 L3 - citeulike-article-id:2216540 TI - Approach to the Prostate Cancer Patient with Bone Disease JF - J Clin Endocrinol Metab VL - 93 IS - 1 SP - 2 EP - 7 N2 - Prostate cancer is the most common visceral malignancy in men. Androgen deprivation therapy (ADT) is commonly used in patients with nonmetastatic prostate cancer and is associated with significant bone loss and fractures. The greatest bone loss occurs during initiation of ADT. Men should have assessment of skeletal integrity with bone mineral density examination by dual x-ray absorptiometry of the hip and spine. Men with fragility fractures or osteoporosis by bone density should be considered for bisphosphonate therapy. Men with low bone mass may need antiresorptive therapy, depending on other risk factors. Men with a normal bone mineral density should be followed up closely with bone densitometry while on ADT. All men should receive preventive measures with calcium (1200 mg daily in divided doses), vitamin D (8001000 IU/d), and weight-bearing exercise. Men should be evaluated for additional secondary causes of bone loss including vitamin D insufficiency. Guidelines are needed for androgen-induced bone loss screening and treatment. 10.1210/jc.2007-1402 KW - cancer KW - osteoporosis KW - sideffects AU - Greenspan, Susan PY - 2008/01/01/ UR - http://dx.doi.org/10.1210/jc.2007-1402 ER -