Dose-Dependent Effects of Testosterone on Regional Adipose Tissue Distribution in Healthy Young Men

@article{citeulike:1803076, abstract = {Testosterone supplementation reduces total body adipose tissue (AT), but we do not know whether the effects are uniformly distributed throughout the body or are region specific, or whether they are dose related. We determined the effects of graded doses of testosterone on regional AT distribution in 54 healthy men (18-35 yr) in a 20-wk, randomized, double-blind study of combined treatment with GnRH agonist plus one of five doses (25, 50, 125, 300, or 600 mg/wk) of testosterone enanthate (TE). Total body, appendicular, and trunk AT and lean body mass were measured by dual-energy x-ray absorptiometry, and sc, intermuscular, and intraabdominal AT of the thigh and abdomen were measured by magnetic resonance imaging. Treatment regimens resulted in serum nadir testosterone concentrations ranging from subphysiological to supraphysiological levels. Dose-dependent changes in AT mass were negatively correlated with TE dose at all sites and were equally distributed between the trunk and appendices. The lowest dose was associated with gains in sc, intermuscular, and intraabdominal AT, with the greatest percent increase occurring in the sc stores. At the three highest TE doses, thigh intermuscular AT volume was significantly reduced, with a greater percent loss in intermuscular than sc depots, whereas intraabdominal AT stores remained unchanged. In conclusion, changes in testosterone concentrations in young men are associated with dose-dependent and region-specific changes in AT and lean body mass in the appendices and trunk. Lowering testosterone concentrations below baseline increases sc and deep AT stores in the appendices and abdomen, with a greater percent increase in sc depots. Conversely, elevating testosterone concentrations above baseline induces a greater loss of AT from the smaller, deeper intermuscular stores of the thigh. 10.1210/jc.2003-031492}, author = {Woodhouse, Linda J. and Gupta, Nidhi and Bhasin, Meenakshi and Singh, Atam B. and Ross, Robert and Phillips, Jeffrey and Bhasin, Shalender }, citeulike-article-id = {1803076}, comment = {The mechanisms by which testosterone administration decreases AT mass are not well understood. Testosterone acts to inhibit lipoprotein lipase (LPL) activity, decrease triglyceride accumulation, and stimulate lipolysis (58, 59). These effects are mediated via the androgen receptor, whose density is up-regulated by testosterone (60). Because androgen receptor density is higher in visceral or intraabdominal than in sc AT in the rat (61) and possibly humans (62), this has led to speculation that the androgen effects should be more pronounced in visceral or intraabdominal than in sc AT stores. Marin et al. (16, 56, 63) have reported that testosterone regulates LPL activity in a region-specific manner. These investigators demonstrated that testosterone administration to abdominally obese middle-aged men decreased LPL activity, inhibited triglyceride uptake, and increased the rate of triglyceride turnover in abdominal but not femoral sc AT, resulting in a net loss of abdominal AT. }, doi = {10.1210/jc.2003-031492}, journal = {J Clin Endocrinol Metab}, keywords = {adiposity, testosterone, therapy}, month = {February}, number = {2}, pages = {718--726}, posted-at = {2008-01-31 02:58:35}, priority = {2}, title = {Dose-Dependent Effects of Testosterone on Regional Adipose Tissue Distribution in Healthy Young Men}, url = {http://dx.doi.org/10.1210/jc.2003-031492}, volume = {89}, year = {2004} }

TY - JOUR ID - citeulike:1803076 L3 - citeulike-article-id:1803076 TI - Dose-Dependent Effects of Testosterone on Regional Adipose Tissue Distribution in Healthy Young Men JF - J Clin Endocrinol Metab VL - 89 IS - 2 SP - 718 EP - 726 N2 - Testosterone supplementation reduces total body adipose tissue (AT), but we do not know whether the effects are uniformly distributed throughout the body or are region specific, or whether they are dose related. We determined the effects of graded doses of testosterone on regional AT distribution in 54 healthy men (18-35 yr) in a 20-wk, randomized, double-blind study of combined treatment with GnRH agonist plus one of five doses (25, 50, 125, 300, or 600 mg/wk) of testosterone enanthate (TE). Total body, appendicular, and trunk AT and lean body mass were measured by dual-energy x-ray absorptiometry, and sc, intermuscular, and intraabdominal AT of the thigh and abdomen were measured by magnetic resonance imaging. Treatment regimens resulted in serum nadir testosterone concentrations ranging from subphysiological to supraphysiological levels. Dose-dependent changes in AT mass were negatively correlated with TE dose at all sites and were equally distributed between the trunk and appendices. The lowest dose was associated with gains in sc, intermuscular, and intraabdominal AT, with the greatest percent increase occurring in the sc stores. At the three highest TE doses, thigh intermuscular AT volume was significantly reduced, with a greater percent loss in intermuscular than sc depots, whereas intraabdominal AT stores remained unchanged. In conclusion, changes in testosterone concentrations in young men are associated with dose-dependent and region-specific changes in AT and lean body mass in the appendices and trunk. Lowering testosterone concentrations below baseline increases sc and deep AT stores in the appendices and abdomen, with a greater percent increase in sc depots. Conversely, elevating testosterone concentrations above baseline induces a greater loss of AT from the smaller, deeper intermuscular stores of the thigh. 10.1210/jc.2003-031492 KW - adiposity KW - testosterone KW - therapy N1 - The mechanisms by which testosterone administration decreases AT mass are not well understood. Testosterone acts to inhibit lipoprotein lipase (LPL) activity, decrease triglyceride accumulation, and stimulate lipolysis (58, 59). These effects are mediated via the androgen receptor, whose density is up-regulated by testosterone (60). Because androgen receptor density is higher in visceral or intraabdominal than in sc AT in the rat (61) and possibly humans (62), this has led to speculation that the androgen effects should be more pronounced in visceral or intraabdominal than in sc AT stores. Marin et al. (16, 56, 63) have reported that testosterone regulates LPL activity in a region-specific manner. These investigators demonstrated that testosterone administration to abdominally obese middle-aged men decreased LPL activity, inhibited triglyceride uptake, and increased the rate of triglyceride turnover in abdominal but not femoral sc AT, resulting in a net loss of abdominal AT. AU - Woodhouse, Linda AU - Gupta, Nidhi AU - Bhasin, Meenakshi AU - Singh, Atam AU - Ross, Robert AU - Phillips, Jeffrey AU - Bhasin, Shalender PY - 2004/02/01/ UR - http://dx.doi.org/10.1210/jc.2003-031492 ER -