Genome-Wide Association Analysis Identifies Loci for Type 2 Diabetes and Triglyceride Levels.

@article{citeulike:1281649, abstract = {New strategies for prevention and treatment of type 2 diabetes (T2D) require improved insight into disease etiology. We analyzed 386,731 common single nucleotide polymorphisms (SNPs) in 1,464 patients with T2D and 1,467 matched controls, each characterized for measures of glucose metabolism, lipids, obesity, and blood pressure. With collaborators (FUSION and WTCCC/UKT2D) we identify and confirm three loci associated with T2D -- in a non-coding region near CDKN2A and CDKN2B, in an intron of IGF2BP2, and an intron of CDKAL1 -- and replicate associations near HHEX and in SLC30A8 found by a recent whole genome association study. We identify and confirm association of a SNP in an intron of glucokinase regulatory protein with serum triglycerides. The discovery of associated variants in unsuspected genes and outside coding regions illustrates the ability of genome-wide association studies to provide potentially important clues into the pathogenesis of common diseases.}, address = {Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA.; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.}, author = {Saxena, Richa and Voight, Benjamin F F. and Lyssenko, Valeriya and Burtt, Noel P P. and de Bakker, Paul I W I. and Chen, Hong and Roix, Jeffrey J J. and Kathiresan, Sekar and Hirschhorn, Joel N N. and Daly, Mark J J. and Hughes, Thomas E E. and Groop, Leif and Altshuler, David and Almgren, Peter and Florez, Jose C C. and Meyer, Joanne and Ardlie, Kristin and Bengtsson, Kristina and Isomaa, Bo and Lettre, Guillaume and Lindblad, Ulf and Lyon, Helen N N. and Melander, Olle and Newton-Cheh, Christopher and Nilsson, Peter and Orho-Melander, Marju and R\r{a}stam, Lennart and Speliotes, Elizabeth K K. and Taskinen, Marja-Riitta R. and Tuomi, Tiinamaija and Guiducci, Candace and Berglund, Anna and Carlson, Joyce and Gianniny, Lauren and Hackett, Rachel and Hall, Liselott and Holmkvist, Johan and Laurila, Esa and Sj\"{o}gren, Marketa and Sterner, Maria and Surti, Aarti and Svensson, Margareta and Svensson, Malin and Tewhey, Ryan and Blumenstiel, Brendan and Parkin, Melissa and Defelice, Matthew and Barry, Rachel and Brodeur, Wendy and Camarata, Jody and Chia, Nancy and Fava, Mary and Gibbons, John and Handsaker, Bob and Healy, Claire and Nguyen, Kieu and Gates, Casey and Sougnez, Carrie and Gage, Diane and Nizzari, Marcia and Gabriel, Stacey B B. and Chirn, Gung-Wei W. and Ma, Qicheng and Parikh, Hemang and Richardson, Delwood and Ricke, Darrell and Purcell, Shaun }, citeulike-article-id = {1281649}, doi = {10.1126/science.1142358}, issn = {1095-9203}, journal = {Science}, keywords = {diabetes, diagnosis, gwa, molecular}, month = {April}, posted-at = {2008-03-14 19:19:19}, priority = {2}, title = {Genome-Wide Association Analysis Identifies Loci for Type 2 Diabetes and Triglyceride Levels.}, url = {http://dx.doi.org/10.1126/science.1142358}, year = {2007} }

TY - JOUR ID - citeulike:1281649 TI - Genome-Wide Association Analysis Identifies Loci for Type 2 Diabetes and Triglyceride Levels. JF - Science AD - Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA.; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA. SN - 1095-9203 N2 - New strategies for prevention and treatment of type 2 diabetes (T2D) require improved insight into disease etiology. We analyzed 386,731 common single nucleotide polymorphisms (SNPs) in 1,464 patients with T2D and 1,467 matched controls, each characterized for measures of glucose metabolism, lipids, obesity, and blood pressure. With collaborators (FUSION and WTCCC/UKT2D) we identify and confirm three loci associated with T2D -- in a non-coding region near CDKN2A and CDKN2B, in an intron of IGF2BP2, and an intron of CDKAL1 -- and replicate associations near HHEX and in SLC30A8 found by a recent whole genome association study. We identify and confirm association of a SNP in an intron of glucokinase regulatory protein with serum triglycerides. The discovery of associated variants in unsuspected genes and outside coding regions illustrates the ability of genome-wide association studies to provide potentially important clues into the pathogenesis of common diseases. KW - diabetes KW - diagnosis KW - gwa KW - molecular AU - Saxena, Richa AU - Voight, Benjamin F AU - Lyssenko, Valeriya AU - Burtt, Noel P AU - de Bakker, Paul I W AU - Chen, Hong AU - Roix, Jeffrey J AU - Kathiresan, Sekar AU - Hirschhorn, Joel N AU - Daly, Mark J AU - Hughes, Thomas E AU - Groop, Leif AU - Altshuler, David AU - Almgren, Peter AU - Florez, Jose C AU - Meyer, Joanne AU - Ardlie, Kristin AU - Bengtsson, Kristina AU - Isomaa, Bo AU - Lettre, Guillaume AU - Lindblad, Ulf AU - Lyon, Helen N AU - Melander, Olle AU - Newton-Cheh, Christopher AU - Nilsson, Peter AU - Orho-Melander, Marju AU - Råstam, Lennart AU - Speliotes, Elizabeth K AU - Taskinen, Marja-Riitta AU - Tuomi, Tiinamaija AU - Guiducci, Candace AU - Berglund, Anna AU - Carlson, Joyce AU - Gianniny, Lauren AU - Hackett, Rachel AU - Hall, Liselott AU - Holmkvist, Johan AU - Laurila, Esa AU - Sjögren, Marketa AU - Sterner, Maria AU - Surti, Aarti AU - Svensson, Margareta AU - Svensson, Malin AU - Tewhey, Ryan AU - Blumenstiel, Brendan AU - Parkin, Melissa AU - Defelice, Matthew AU - Barry, Rachel AU - Brodeur, Wendy AU - Camarata, Jody AU - Chia, Nancy AU - Fava, Mary AU - Gibbons, John AU - Handsaker, Bob AU - Healy, Claire AU - Nguyen, Kieu AU - Gates, Casey AU - Sougnez, Carrie AU - Gage, Diane AU - Nizzari, Marcia AU - Gabriel, Stacey B AU - Chirn, Gung-Wei AU - Ma, Qicheng AU - Parikh, Hemang AU - Richardson, Delwood AU - Ricke, Darrell AU - Purcell, Shaun PY - 2007/04/26/ UR - http://dx.doi.org/10.1126/science.1142358 ER -