A human protein atlas based on antibody proteomics.

by: A Persson, S Hober, M Uhlén

Curr Opin Mol Ther, Vol. 8, No. 3. (June 2006), pp. 185-190.

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antibody, antibody-array, proteomics

Abstract

The Human Protein Atlas is a comprehensive database that provides the protein expression profiles for a large number of human proteins, presented as immunohistological images from most human tissues. This review provides an overview of the contents of the atlas, discusses the project strategy and highlights the importance of open access for data validation and quality. Essential procedures that are implemented during antibody production and image generation, such as the use of protein epitope signature tags (PrEST) antigens, monospecific antibodies, tissue microarrays and thorough quality validation, are also discussed. The Human Protein Atlas is related to four other expression atlas initiatives, including, in particular, an upcoming protein atlas developed by the Sanger Institute.

@article{citeulike:2048971, abstract = {The Human Protein Atlas is a comprehensive database that provides the protein expression profiles for a large number of human proteins, presented as immunohistological images from most human tissues. This review provides an overview of the contents of the atlas, discusses the project strategy and highlights the importance of open access for data validation and quality. Essential procedures that are implemented during antibody production and image generation, such as the use of protein epitope signature tags (PrEST) antigens, monospecific antibodies, tissue microarrays and thorough quality validation, are also discussed. The Human Protein Atlas is related to four other expression atlas initiatives, including, in particular, an upcoming protein atlas developed by the Sanger Institute.}, address = {Royal Institute of Technology, School of Biotechnology, AlbaNova University Center, SE-106 91 Stockholm, Sweden. anja@biotech.kth.se}, author = {Persson, A. and Hober, S. and Uhl\'{e}n, M. }, citeulike-article-id = {2048971}, issn = {1464-8431}, journal = {Curr Opin Mol Ther}, keywords = {antibody, antibody-array, proteomics}, month = {June}, number = {3}, pages = {185--190}, posted-at = {2007-12-03 10:47:04}, priority = {4}, title = {A human protein atlas based on antibody proteomics.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/16774037}, volume = {8}, year = {2006} }

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TY - JOUR ID - citeulike:2048971 L3 - citeulike-article-id:2048971 TI - A human protein atlas based on antibody proteomics. JF - Curr Opin Mol Ther VL - 8 IS - 3 SP - 185 EP - 190 AD - Royal Institute of Technology, School of Biotechnology, AlbaNova University Center, SE-106 91 Stockholm, Sweden. anja@biotech.kth.se SN - 1464-8431 N2 - The Human Protein Atlas is a comprehensive database that provides the protein expression profiles for a large number of human proteins, presented as immunohistological images from most human tissues. This review provides an overview of the contents of the atlas, discusses the project strategy and highlights the importance of open access for data validation and quality. Essential procedures that are implemented during antibody production and image generation, such as the use of protein epitope signature tags (PrEST) antigens, monospecific antibodies, tissue microarrays and thorough quality validation, are also discussed. The Human Protein Atlas is related to four other expression atlas initiatives, including, in particular, an upcoming protein atlas developed by the Sanger Institute. KW - antibody KW - antibody-array KW - proteomics AU - Persson, A AU - Hober, S AU - Uhlén, M PY - 2006/06// UR - http://view.ncbi.nlm.nih.gov/pubmed/16774037 ER -

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